ArticleAngewandte Chemie (International ed. in English)2022
A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.
Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 53 citations in OpenAlex.
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- Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation.Angewandte Chemie (International ed. in English) · 2025Article
- Dynamic covalent synthesis.Chemical science · 2024Review
- Transitioning from Supramolecular Chemistry to Molecularly Imprinted Polymers in Chemical Sensing.Sensors (Basel, Switzerland) · 2023Article
- A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.Angewandte Chemie (International ed. in English) · 2022Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3-Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation-associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3-nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease.
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