Evidence map›Paper›PMID 35511045›Full record

ArticleBiochemistry2022

The DNA-Binding High-Mobility Group Box Domain of Sox Family Proteins Directly Interacts with RNA

Desmond J Hamilton, Abigail E Hein, Zachariah E Holmes, Deborah S Wuttke, Robert T Batey

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Desmond J HamiltonDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309-0596, United States.
Abigail E HeinDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309-0596, United States.
Zachariah E HolmesDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309-0596, United States.
Deborah S WuttkeDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309-0596, United States.ORCID 0000-0002-8158-8795
Robert T BateyDepartment of Biochemistry, University of Colorado Boulder, Boulder, Colorado 80309-0596, United States.ORCID 0000-0002-1384-6625
University of Colorado Boulder · US

Funding

Predoctoral Training Molecular BiophysicsT32GM065103 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 2002 to 2021
$4.3M
RNA Regulation of Transcription Factor ActivityR01GM120347 · NIGMS · UNIVERSITY OF COLORADO · PI WUTTKE, DEBORAH S. · 2016 to 2024
$3.2M
NIGMS NIH HHS R01 GM120347NIGMS NIH HHS T32 GM065103
6 · The paper itself

Abstract

There is a growing body of evidence that a substantial number of protein domains identified as DNA-binding also interact with RNA to regulate biological processes. Several recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain

Identifiers

PMID35511045
PMCPMC9636074
OpenAlexW4229028240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.