Evidence map›Paper›PMID 35510955›Full record

ArticleEMBO molecular medicine2022

A preclinical model of peripheral T-cell lymphoma GATA3 reveals DNA damage response pathway vulnerability.

Elizabeth A Kuczynski, Giulia Morlino, Alison Peter, Anna M L Coenen-Stass, Jennifer I Moss, Neha Wali, Oona Delpuech, Avinash Reddy, Anisha Solanki, Charles Sinclair and 2 more

Open access · goldAbstract read
In one paragraph

Article in EMBO molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Applications of Flow Cytometry in Drug Discovery and Translational Research.International journal of molecular sciences · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 5 countries.

Elizabeth A KuczynskiOncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0002-6924-6848
Giulia MorlinoImmunity & Cancer Laboratory, Francis Crick Institute, London, UK.
Alison PeterOncology R&D, AstraZeneca, Cambridge, UK.
Anna M L Coenen-StassOncology R&D, AstraZeneca, Cambridge, UK.
Jennifer I MossOncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0003-0923-229X
Neha WaliOncology R&D, AstraZeneca, Cambridge, UK.
Oona DelpuechOncology R&D, AstraZeneca, Cambridge, UK.
Avinash ReddyOncology R&D, AstraZeneca, Waltham, MA, USA.
Anisha SolankiOncology R&D, AstraZeneca, Cambridge, UK.
Charles SinclairOncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0001-6857-9993
Dinis P CaladoImmunity & Cancer Laboratory, Francis Crick Institute, London, UK.ORCID 0000-0001-8239-7184
Larissa S CarnevalliOncology R&D, AstraZeneca, Cambridge, UK.ORCID 0000-0001-7432-0195
AstraZeneca (United Kingdom) · GBThe Francis Crick Institute · GBAstraZeneca (South Korea) · KR

Funding

Cancer Research UK 16857Medical Research Council MR/J008060/1Wellcome Trust FC001057
6 · The paper itself

Abstract

Peripheral T-cell lymphoma (PTCL) represents a rare group of heterogeneous diseases in urgent need of effective treatments. A scarcity of disease-relevant preclinical models hinders research advances. Here, we isolated a novel mouse (m)PTCL by serially transplanting a lymphoma from a germinal center B-cell hyperplasia model (Cγ1-Cre Blimp1

Indexed as

DNA DamageGATA3 Transcription FactorLymphoma, T-Cell, PeripheralAnimalsB-LymphocytesMiceT-LymphocytesGata3 protein, mouseGATA3 Transcription FactorDNA damage responseGATA3peripheral T-cell lymphomasyngeneic mouse modelT-follicular helper cell

Identifiers

PMID35510955
PMCPMC9174882
OpenAlexW4229027569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.