ArticleeLife2022
Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Common neural dysfunction in psychiatric disorders: Insights from a meta-analysis of resting-state fMRI studies.Translational psychiatry · 2025Pooled it
- The prefrontal cortex across scales: laminar architecture, white-matter constraints, and distributed control in cognition.Brain structure & function · 2026Review
- Ventrolateral prefrontal cortex in macaques guides decisions in different learning conditions.Nature communications · 2026Article
- A human subcortical connectome at 400 μm resolution.bioRxiv : the preprint server for biology · 2026Article
- Dissociating the Role of Dorsolateral Prefrontal Cortex and Ventrolateral Prefrontal Cortex in Cognitive Control in Depression: A Combined HD-tDCS and fNIRS Study.Brain topography · 2025Article
- Subcortical modulation of the salience network during negative emotional processing in mood and anxiety disorders.Molecular psychiatry · 2025Article
- High Beta Power in the Ventrolateral Prefrontal Cortex Indexes Human Approach Behavior: A Case Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning.bioRxiv : the preprint server for biology · 2025Article
- Resilience of Neural Networks Underlying the Stroop Effect in the Aftermath of Severe COVID-19: fMRI Pilot Study.Brain sciences · 2025Article
- An interpretable framework for gastric cancer classification using multi-channel attention mechanisms and transfer learning approach on histopathology images.Scientific reports · 2025Article
- Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial.Journal of mood and anxiety disorders · 2025Article
- Sex-specific cerebrovascular reactivity differences in autistic children related to functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Democratizing technologies in psychiatry: non-human primate neuroanatomy paves the way for accessible neurofeedback in the wild.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Translation of monosynaptic circuits underlying amygdala fMRI neurofeedback training.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Article
- Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dorsal Anterior Cingulate Cortex Coordinates Contextual Mental Imagery for Single-Beat Manipulation during Rhythmic Sensorimotor Synchronization.Brain sciences · 2024Article
- Article
- Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study.The journal of headache and pain · 2024Article
- Dissociable representations of decision variables within subdivisions of macaque orbitofrontal and ventrolateral frontal cortex.bioRxiv : the preprint server for biology · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Three large-scale networks are considered essential to cognitive flexibility: the ventral and dorsal attention (VANet and DANet) and salience (SNet) networks. The ventrolateral prefrontal cortex (vlPFC) is a known component of the VANet and DANet, but there is a gap in the current knowledge regarding its involvement in the SNet. Herein, we used a translational and multimodal approach to demonstrate the existence of a SNet node within the vlPFC. First, we used tract-tracing methods in non-human primates (NHP) to quantify the anatomical connectivity strength between different vlPFC areas and the frontal and insular cortices. The strongest connections were with the dorsal anterior cingulate cortex (dACC) and anterior insula (AI) - the main cortical SNet nodes. These inputs converged in the caudal area 47/12, an area that has strong projections to subcortical structures associated with the SNet. Second, we used resting-state functional MRI (rsfMRI) in NHP data to validate this SNet node. Third, we used rsfMRI in the human to identify a homologous caudal 47/12 region that also showed strong connections with the SNet cortical nodes. Taken together, these data confirm a SNet node in the vlPFC, demonstrating that the vlPFC contains nodes for all three cognitive networks: VANet, DANet, and SNet. Thus, the vlPFC is in a position to switch between these three networks, pointing to its key role as an attentional hub. Its additional connections to the orbitofrontal, dorsolateral, and premotor cortices, place the vlPFC at the center for switching behaviors based on environmental stimuli, computing value, and cognitive control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.