Evidence map›Paper›PMID 35510621›Full record

ReviewPhotodermatology, photoimmunology & photomedicine2023

Physical properties and biological effects of ceramic materials emitting infrared radiation for pain, muscular activity, and musculoskeletal conditions.

Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin

2 registry-linked trialsOpen access · hybridAbstract readReview
In one paragraph

Review in Photodermatology, photoimmunology & photomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06452914 narecruitingnot on this mapstarted 2024, after this paper: background citation

Clinical Outcomes Related to Treatment of Distal Symmetric Polyneuropathy Using Semiconductor Embedded Therapeutic Socks

TypeinterventionalSponsorEndocrine Research SolutionsRan2024 to 2025Enrolled80ConditionsDiabetic NeuropathyArmsSemiconductor Embedded Therapeutic Socks, Placebo Socks
NCT06846593 naterminatednot on this mapstarted 2024, after this paper: background citation

The Comparison and Combination of Semiconductor Embedded Therapeutic Arm Sleeves and Platelet-Rich Plasma With Adipose Stem Cell (PRP+ASC) Injections for the Treatment of ECRB Tendinopathy (Lateral Epicondylitis): A Randomized, Double-Blinded, Placebo-Controlled Prospective Clinical Trial

TypeinterventionalSponsorINCREDIWEAR HOLDINGS, INC.Ran2024 to 2026Enrolled5ConditionsECRB TendinopathyArmsSemiconductor Embedded Therapeutic Arm Sleeves, Placebo Arm Sleeves, Platelet-Rich Plasma with Adipose Stem Cell (PRP+ASC) Injections
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
  2. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 4 countries.

Jan KyselovicClinical Research Unit, 5th Department of Internal Medicine, Faculty of Medicine, Comenius University, University Hospital Bratislava, Bratislava, Slovak Republic.ORCID https://orcid.org/0000-0001-9208-5352
Jozef MasarikDepartment of Nuclear Physics and Biophysics, Faculty of Mathematics, Physics, and Informatics, Comenius University Bratislava, Bratislava, Slovak Republic.
Hayet KechemirConsumer Healthcare Medical Affairs Department, Sanofi CHC, Paris, France.
Eva KoscovaConsumer Healthcare Medical Affairs Department, Bratislava, Slovakia.
Iva Igracki TurudicConsumer Healthcare Medical Affairs Department, Sanofi CHC, Frankfurt, Germany.
Michael Richard HamblinLaser Research Centre, Faculty of Health Science, University of Johannesburg, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-6431-4605
Comenius University Bratislava · SKSanofi (France) · FRSanofi (Germany) · DESlovak Medical University · SKUniversity Hospital Bratislava · SKUniversity of Johannesburg · ZA

Funding

Sanofi
6 · The paper itself

Abstract

backgroundUp to 33% of the general population worldwide suffer musculoskeletal conditions, with low back pain being the single leading cause of disability globally. Multimodal therapeutic options are available to relieve the pain associated with muscular disorders, including physical, complementary, and pharmacological therapies. However, existing interventions are not disease modifying and have several limitations.

methodLiterature review.

resultsIn this context, the use of nonthermal infrared light delivered via patches, fabrics, and garments containing infrared-emitting bioceramic minerals have been investigated. Positive effects on muscular cells, muscular recovery, and reduced inflammation and pain have been reported both in preclinical and clinical studies. There are several hypotheses on how infrared may contribute to musculoskeletal pain relief, however, the full mechanism of action remains unclear. This article provides an overview of the physical characteristics of infrared radiation and its biological effects, focusing on those that could potentially explain the mechanism of action responsible for the relief of musculoskeletal pain.

conclusionsBased on the current evidence, the following pathways have been considered: upregulation of endothelial nitric oxide synthase, increase in nitric oxide bioavailability, anti-inflammatory effects, and reduction in oxidative stress.

Indexed as

Musculoskeletal PainCeramicsHumansInfrared RaysTextilesbioceramicinfraredmechanism of actionmusculoskeletal pain

Identifiers

PMID35510621
PMCPMC10084378
OpenAlexW4229045931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.