Evidence map›Paper›PMID 35510553›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2022

Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm.

Daniel J Tyrrell, Judy Chen, Benjamin Y Li, Sherri C Wood, Wendy Rosebury-Smith, Henriette A Remmer, Longtan Jiang, Min Zhang, Morgan Salmon, Gorav Ailawadi and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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  8. Cardiovascular aging: spotlight on mitochondria.American journal of physiology. Heart and circulatory physiology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Daniel J TyrrellDepartment of Internal Medicine (D.J.T., J.C., B.Y.L., S.C.W., D.R.G.), University of Michigan, Ann Arbor.ORCID 0000-0002-0811-6724
Judy ChenDepartment of Internal Medicine (D.J.T., J.C., B.Y.L., S.C.W., D.R.G.), University of Michigan, Ann Arbor.
Benjamin Y LiDepartment of Internal Medicine (D.J.T., J.C., B.Y.L., S.C.W., D.R.G.), University of Michigan, Ann Arbor.
Sherri C WoodDepartment of Internal Medicine (D.J.T., J.C., B.Y.L., S.C.W., D.R.G.), University of Michigan, Ann Arbor.
Wendy Rosebury-SmithUnit for Laboratory Animal Management (W.R.-S.), University of Michigan, Ann Arbor.
Henriette A RemmerProteomics & Peptide Synthesis Core (H.A.R.), University of Michigan, Ann Arbor.
Longtan JiangDepartment of Cardiac Surgery (L.J., M.S., G.A., B.Y.), University of Michigan, Ann Arbor.
Min ZhangDepartment of Biostatistics (M.Z.), University of Michigan, Ann Arbor.
Morgan SalmonDepartment of Cardiac Surgery (L.J., M.S., G.A., B.Y.), University of Michigan, Ann Arbor.
Gorav AilawadiDepartment of Cardiac Surgery (L.J., M.S., G.A., B.Y.), University of Michigan, Ann Arbor.
Bo YangDepartment of Cardiac Surgery (L.J., M.S., G.A., B.Y.), University of Michigan, Ann Arbor.ORCID 0000-0002-2158-9155
Daniel R GoldsteinDepartment of Internal Medicine (D.J.T., J.C., B.Y.L., S.C.W., D.R.G.), University of Michigan, Ann Arbor.ORCID 0000-0001-6695-979X
University of Michigan · USChemical Synthesis Lab · SGVA Center for Clinical Management Research · US

Funding

MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3M
Mechanisms to augment primary immunity in agingR01AG028082 · NIA · YALE UNIVERSITY · PI DENG, JANE C · 2007 to 2023
$6.9M
Physician Scientist Training in Age-Related DiseasesT32AG062403 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MIN, LILLIAN CHIANG, MODY, LONA · 2020 to 2025
$2.7M
The Role of IL-1R1 in cell transitions in Aortic Aneurysm PathogenesisR01HL126668 · NHLBI · UNIVERSITY OF VIRGINIA · PI AILAWADI, GORAV · 2015 to 2019
$2.4M
Role of mitophagy in age-related respiratory and vascular diseasesR35HL155169 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTEIN, DANIEL ROBERT · 2021 to 2023
$1.8M
Cerebrovascular Mitochondrial Function in Aging and Ischemic InjuryR00AG068309 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TYRRELL, DANIEL · 2022 to 2024
$744k
Immune Basis of how Inflammation, Atherosclerosis, and Aging Enhance Atrial FibrillationF32HL140728 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TYRRELL, DANIEL · 2018 to 2020
$165k
Cerebrovascular Mitochondrial Function in Aging and Ischemic InjuryK99AG068309 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TYRRELL, DANIEL · 2021 to 2022
$131k
Interrogating the Effects of Aging on Influenza Infections: The Role of Prostaglandin E2F31HL158003 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, JUDY · 2021 to 2023
$83k
NHLBI NIH HHS F31 HL158003NHLBI NIH HHS F32 HL140728NHLBI NIH HHS R01 HL126668NHLBI NIH HHS R35 HL155169NIA NIH HHS K99 AG068309NIA NIH HHS R00 AG068309NIA NIH HHS R01 AG028082NIA NIH HHS T32 AG062403NIGMS NIH HHS T32 GM007863
6 · The paper itself

Abstract

backgroundAging enhances most chronic diseases but its impact on human aortic tissue in health and in thoracic aortic aneurysms (TAA) remains unclear.

methodsWe employed a human aortic biorepository of healthy specimens (n=17) and those that underwent surgical repair for TAA (n=20). First, we performed proteomics comparing aortas of healthy donors to aneurysmal specimens, in young (ie, <60 years of age) and old (ie, ≥60 years of age) subjects. Second, we measured proteins, via immunoblotting, involved in mitophagy (ie, Parkin) and also mitochondrial-induced inflammatory pathways, specifically TLR (toll-like receptor) 9, STING (stimulator of interferon genes), and IFN (interferon)-β.

resultsProteomics revealed that aging transformed the aorta both quantitatively and qualitatively from health to TAA. Whereas young aortas exhibited an enrichment of immunologic processes, older aortas exhibited an enrichment of metabolic processes. Immunoblotting revealed that the expression of Parkin directly correlated to subject age in health but inversely to subject age in TAA. In TAA, but not in health, phosphorylation of STING and the expression of IFN-β was impacted by aging regardless of whether subjects had bicuspid or tricuspid valves. In subjects with bicuspid valves and TAAs, TLR9 expression positively correlated with subject age. Interestingly, whereas phosphorylation of STING was inversely correlated with subject age, IFN-β positively correlated with subject age.

conclusionsAging transforms the human aortic proteome from health to TAA, leading to a differential regulation of biological processes. Our results suggest that the development of therapies to mitigate vascular diseases including TAA may need to be modified depending on subject age.

Indexed as

Aortic Aneurysm, ThoracicAgingAortaHumansInterferonsProteomeUbiquitin-Protein LigasesInterferonsProteomeUbiquitin-Protein Ligasesagingaortic aneurysm, thoracicchronic diseasesimmunoblottingproteomics

Identifiers

PMID35510553
PMCPMC9339483
OpenAlexW4229029345

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.