Evidence map›Paper›PMID 35510540›Full record

ReviewNeurourology and urodynamics2022

Barriers and facilitators to overactive bladder therapy adherence.

Ekene A Enemchukwu, Leslee L Subak, Alayne Markland

Open access · greenAbstract readReview
In one paragraph

Review in Neurourology and urodynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Health Disparities and Overactive Bladder: Bridging the Gap.Current bladder dysfunction reports · 2026
    Review
  9. Review
  10. Observational
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ekene A EnemchukwuDepartment of Urology, Stanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0001-6224-6207
Leslee L SubakDepartment of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, California, USA.
Alayne MarklandDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.ORCID 0000-0002-6567-6744
Palo Alto University · USUniversity of Alabama at Birmingham · US

Funding

Research and Mentoring Program in Improving Access to Incontinence Care for Older AdultsK24AG073586 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Alayne Denise Markland · 2022 to 2026
$619k
NIA NIH HHS K24 AG073586
6 · The paper itself

Abstract

aimsTo provide an overview of the barriers and facilitators to overactive bladder (OAB) therapy initiation and adherence.

methodsA PubMed and Embase literature search was conducted to identify barriers to OAB therapy adherence.

resultsOAB therapy adherence is associated with improvements in urinary symptoms, and quality of life with reductions in annual costs for OAB-related expenditures. However, adherence rates to behavioral therapies are as low as 32% at 1 year, only 15%-40% of treated patients remain on oral medications at 1 year due to several factors (e.g., inadequate efficacy, tolerability, and cost), and 5%-10% of OAB patients progress to advanced therapies. While some common barriers to therapy adherence are often fixed (e.g., costs, lack of efficacy, time, side effects, treatment fatigue), many are modifiable (e.g., lack of knowledge, poor relationships, negative experiences, poor communication with providers). Patient-centered care may help address some modifiable barriers. Emerging data demonstrate that patient-centered care in the form of treatment navigators improves OAB therapy adherence and progression to advanced therapies in the appropriate patient.

conclusionsThere are numerous modifiable barriers to OAB therapy adherence. A patient-centered lens is needed to elicit patient goals, establish realistic treatment expectations, and tailor therapy to improve therapy adherence, optimize outcomes, and reduce healthcare expenditures. Further research is needed to develop and study low-cost, scalable solutions.

Indexed as

Urinary Bladder, OveractiveHumansPatient ComplianceQuality of Lifebehavioral therapyoveractive bladderpatient-centered carepharmacotherapytherapy adherencethird-line therapyurinary incontinence

Identifiers

PMID35510540
PMCPMC11424050
OpenAlexW4229019270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.