Evidence map›Paper›PMID 35510527›Full record

ArticleBrain and behavior2022

Brain responses to painful electrical stimuli and cognitive tasks interact in the precuneus, posterior cingulate cortex, and inferior parietal cortex and do not vary across the menstrual cycle.

Dieuwke S Veldhuijzen, Timothy J Meeker, Deborah Bauer, Michael L Keaser, Rao P Gullapalli, Joel D Greenspan

Abstract read
In one paragraph

Article in Brain and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Dieuwke S VeldhuijzenInstitute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, the Netherlands.
Timothy J MeekerDepartment of Neurosurgery, Johns Hopkins University, Baltimore, Maryland.
Deborah BauerDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland.
Michael L KeaserDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland.
Rao P GullapalliDepartment of Diagnostic Radiology and Nuclear Imaging, University of Maryland School of Medicine, Baltimore, Maryland.
Joel D GreenspanDepartment of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland.

Funding

Zonulin Antibodies in Intestinal Permeabilitiy in IDDMM01RR016500 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI EDELMAN, MARTIN J. · 2002 to 2009
$20.2M
Sex Differences in Visceral Pain: Influence of Gonadal SteroidsP50AR049555 · NIAMS · UNIVERSITY OF MARYLAND BALTIMORE · PI GREENSPAN, JOEL D. · 2002 to 2006
$5.3M
NCRR NIH HHS M01 RR016500NIAMS NIH HHS P50 AR049555
6 · The paper itself

Abstract

introductionBidirectional effects between cognition and pain have been extensively reported. Although brain regions involved in cognitive and pain processing seem to partly overlap, it is unknown what specific brain regions are involved in the interaction between pain and cognition. Furthermore, the role of gonadal hormones on these interacting effects has not been examined. This study investigated brain activation patterns of the interaction between pain and cognition over different phases of the naturally occurring menstrual cycle.

methodsFifteen healthy normally cycling females were examined over the course of 4 different cycle phases. Sensory stimulation was applied using electrical pulses and cognitive performance was assessed using the Multi-Source Interference Task. Brain imaging consisted of functional magnetic resonance imaging using a repeated measures ANOVA group analysis approach.

resultsSensory stimulation was found to interact with task performance in the left precuneus, left posterior cingulate cortex and right inferior parietal lobule. No effects of cycle phase were observed to interact with main effects of stimulation, task or interaction effects between task performance and sensory stimulation.

conclusionPotential neural correlates of shared resources between pain and cognition were demonstrated providing further insights into the potential mechanisms behind cognitive performance difficulties in pain patients and opening avenues for new treatment options including targeting specific cognitive factors in pain treatment such as cognitive interference.

Indexed as

BrainGyrus CinguliBrain MappingCognitionFemaleHumansMagnetic Resonance ImagingMenstrual CyclePainParietal Lobecognitive performanceelectrical paingonadal hormonesmenstrual cycleMSIT

Identifiers

PMID35510527
PMCPMC9226794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.