SynthesisInternational wound journal2022
Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis.
Synthesis in International wound journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05908968 (A Pilot Study to Assess the Effects of Oxygen-enriched Water), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study to Assess the Effects of Oxygen-enriched Water (ELO Water) on Wound Healing for Diabetic Foot Ulcers
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Efficacy and safety of topical oxygen therapy for diabetic foot ulcers: An updated systematic review and meta-analysis.International wound journal · 2022Pooled it
- Clinical Efficacy and Safety of Portable Continuous Topical Oxygen Therapy for Chronic Wound Management: A Randomised Controlled Trial.International wound journal · 2026Trial
- 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Pioneering Topical Ointment Intervention for Unprecedented Antimicrobial and Diabetic Wound Management with Phenylpropanoids and Nano-Silver.The AAPS journal · 2024Article
- Topical oxygen therapy and singlet oxygen in wound healing: A scoping review.International wound journal · 2024Article
- Systematic review of the effects of topical oxygen therapy on wound healing.JVS-vascular insights · 2024Article
- 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- Treatment of Medication-Related Osteonecrosis of the Jaws (MRONJ) with Topical Therapy Using Active Oxygen Gel.Clinical, cosmetic and investigational dentistry · 2024Article
- Article
- KADAM topical warm oxygen therapy device for diabetic foot ulcer-a novel approach.Journal of diabetes and metabolic disorders · 2023Article
- HPharmaceutics · 2023Article
- 12. Retinopathy, Neuropathy, and Foot Care: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- A Narrative Review on Means to Promote Oxygenation and Angiogenesis in Oral Wound Healing.Bioengineering (Basel, Switzerland) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To evaluate the efficacy and safety of topical oxygen therapy (TOT) in diabetic foot ulcers (DFUs), researchers systematically retrieved relevant studies from PubMed, EMBASE, Web of Science, CENTRAL and ClinicalTrials.gov. Relevant studies were searched from database inception to January 2022. Two researchers independently screened the literature, extracted data and assessed the quality of the included studies. Statistical analysis was performed in Stata 16.0. A total of seven RCTs involving 614 participants were included. Compared with the control group, the TOT group had a higher healing rate (RR = 1.63, 95% CI [1.33, 2.00]). According to descriptive analysis, TOT reduced the ulcer area and improved healing durability and quality of life. Furthermore, it had no effect on the occurrence of adverse events. However, it was unclear whether it would be able to reduce the healing time. The existing evidence suggests that TOT is effective and safe for chronic DFUs. Further studies are warranted to validate our findings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.