Evidence map›Paper›PMID 35510509›Full record

ArticleJournal of clinical microbiology2022

Time to Clearance of Neisseria gonorrhoeae RNA at the Pharynx following Treatment.

Lindley A Barbee, Olusegun O Soge, Christine M Khosropour, Angela LeClair, Matthew R Golden

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Observational
  2. To culture or not to culture: correlatingSexually transmitted infections · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindley A BarbeeUniversity of Washingtongrid.34477.33grid.471394.cgrid.34477.33, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, Washington, USA.ORCID 0000-0002-7189-5492
Olusegun O SogeUniversity of Washingtongrid.34477.33grid.471394.cgrid.34477.33, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, Washington, USA.ORCID 0000-0002-8504-2319
Christine M KhosropourUniversity of Washingtongrid.34477.33grid.471394.cgrid.34477.33, Department of Epidemiology, Seattle, Washington, USA.
Angela LeClairUniversity of Washingtongrid.34477.33grid.471394.cgrid.34477.33, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, Washington, USA.
Matthew R GoldenUniversity of Washingtongrid.34477.33grid.471394.cgrid.34477.33, Department of Medicine, Division of Allergy and Infectious Diseases, Seattle, Washington, USA.

Funding

A Prospective Cohort Study to Determine Optimal Timing of Test of Cure for Pharyngeal Gonorrhea with NAATR03AI140183 · NIAID · UNIVERSITY OF WASHINGTON · PI BARBEE, LINDLEY · 2018 to 2019
$155k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (DIR, NIAID) AI140183-01NIAID NIH HHS R03 AI140183
6 · The paper itself

Abstract

The number of days until pharyngeal Neisseria gonorrhoeae nucleic acid amplification test (NAAT) results become negative after treatment remains unknown. Between March 2019 and April 2021, we enrolled men who have sex with men (MSM) who had a clinical positive pharyngeal N. gonorrhoeae Aptima Combo 2 test result but had not yet been treated in a prospective longitudinal cohort study. MSM were enrolled on their day of treatment and self-collected daily pharyngeal specimens for 21 days at home. We used Kaplan-Meier estimates to determine the median time to clearance and the >95% time to clearance and the log rank test for equality to evaluate factors associated with time to clearance. Sixty-four men were enrolled in the study. Analyses excluded 8 men (12.5%) who were N. gonorrhoeae negative by NAAT at enrollment and 11 (17%) who failed to return any home-collected specimens. Among the 45 men included in the analysis, the median time to N. gonorrhoeae NAAT clearance was 3 days (95% confidence interval [CI], 2 to 5 days). Time to clearance for >95% of the cohort was 12 days (95% CI, 10 days to an undefined time). Men with a history of N. gonorrhoeae infection cleared faster than men without such history (8 days versus 17 days for >95% time to clearance;

Indexed as

Chlamydia InfectionsGonorrheaSexual and Gender MinoritiesChlamydia trachomatisHomosexuality, MaleHumansLongitudinal StudiesMaleNeisseria gonorrhoeaeNucleic Acid Amplification TechniquesPharynxProspective StudiesRNARNAclearanceNAATNeisseria gonorrhoeae

Identifiers

PMID35510509
PMCPMC9199414

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.