Evidence map›Paper›PMID 35509846›Full record

ArticleJournal of oncology2022

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents.

Reem Altaf, Humaira Nadeem, Umair Ilyas, Jamshed Iqbal, Rehan Zafar Paracha, Hajra Zafar, Ana Cláudia Paiva-Santos, Muhammad Sulaiman, Faisal Raza

Abstract read
In one paragraph

Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Identification of Novel Progesterone Receptor (PR) Inhibitors (Pharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Reem AltafDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan.ORCID https://orcid.org/0000-0003-3850-4944
Humaira NadeemDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan.
Umair IlyasDepartment of Pharmaceutics, Faculty of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.
Jamshed IqbalCentre for Advanced Drug Research, COMSATS University Islamabad, Abbottabad Campus, Abbottabad, Pakistan.
Rehan Zafar ParachaResearch Center for Modeling & Simulation (RCMS), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Hajra ZafarSchool of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan, Road, Shanghai 200240, China.ORCID https://orcid.org/0000-0002-0606-5783
Ana Cláudia Paiva-SantosDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal.ORCID https://orcid.org/0000-0003-2710-6000
Muhammad SulaimanFaculty of Pharmacy, Capital University of Science & Technology, Islamabad, Pakistan.
Faisal RazaSchool of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan, Road, Shanghai 200240, China.ORCID https://orcid.org/0000-0001-5569-3535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because of the high incidence and mortality rate of breast cancer, there is a dire need of discovering new pharmacotherapeutic agents in managing this disease. A series of twenty-two derivatives of

Identifiers

PMID35509846
PMCPMC9061032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.