Evidence map›Paper›PMID 35509845›Full record

ArticleJournal of oncology2022

Comparative Analysis of Proteomic of Curcumin Reversing Multidrug Resistance in HCT-8/VCR Cells.

Lei Li, Libo Yu, Xiansheng Cao, Chao Zhang, Qi Liu, Jun Chen

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lei LiDepartment of Gastrointestinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.ORCID https://orcid.org/0000-0002-2904-2242
Libo YuDepartment of Radiology, Yantaishan Hospital, Yantai, China.
Xiansheng CaoDepartment of Gastrointestinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Chao ZhangDepartment of Gastrointestinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Qi LiuDepartment of Gastrointestinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Jun ChenDepartment of Gastrointestinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.ORCID https://orcid.org/0000-0002-5886-3656
Binzhou Medical University · CNYantaishan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To further explore the mechanisms of curcumin reversing multidrug resistance (MDR) in HCT8/VCR cells. Here, we employed comparative analysis of proteomic of essential proteins of human colon carcinoma HCT8/VCR cells with or without treatment of curcumin by separating and quantifying the essential protein posttranslational modification through radical-free two-dimensional polyacrylamide gel electrophoresis with strong reductant. The reverse impact of curcumin on multidrug resistance of HCT8/VCR and HCT8/VCR cells was evaluated using MTT assay. After adding curcumin 25

Identifiers

PMID35509845
PMCPMC9061040
OpenAlexW4224623391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.