Evidence map›Paper›PMID 35509637›Full record

ArticleJBMR plus2022

Vitamin D Supplementation for 12 Months in Older Adults Alters Regulators of Bone Metabolism but Does Not Change Wnt Signaling Pathway Markers.

Marilena Christodoulou, Terence J Aspray, Isabelle Piec, Christopher Washbourne, Jonathan Cy Tang, William D Fraser, Inez Schoenmakers, VDOP Trial Group

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Longitudinal comparison of bone, growth, and biochemical markers in breastfed HIV-exposed uninfected and HIV-unexposed Ugandan children.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Biochemical Markers of Calcium and Bone Metabolism during and after Lactation in Ugandan Women with HIV on Universal Maternal Antiretroviral Therapy.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marilena ChristodoulouMedical School University of East Anglia Norwich UK.ORCID https://orcid.org/0000-0002-5637-3768
Terence J AsprayFreeman Hospital, Bone Clinic University of Newcastle upon Tyne Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0001-9522-6069
Isabelle PiecMedical School University of East Anglia Norwich UK.
Christopher WashbourneMedical School University of East Anglia Norwich UK.ORCID https://orcid.org/0000-0003-0611-4220
Jonathan Cy TangMedical School University of East Anglia Norwich UK.
William D FraserMedical School University of East Anglia Norwich UK.
Inez SchoenmakersMedical School University of East Anglia Norwich UK.
VDOP Trial Group
University of East Anglia · GBFreeman Hospital · GBRogers (United States) · US

Funding

Versus Arthritis 19544
6 · The paper itself

Abstract

Vitamin D status and supplementation regulates bone metabolism and may modulate Wnt signaling. We studied the response of hormonal regulators of bone metabolism, markers of Wnt signaling and bone turnover and bone mineral density (BMD) and bone mineral content (BMC) in a randomized vitamin D intervention trial (12,000 IU, 24,000 IU, 48,000 IU/mo for 1 year; men and women aged >70 years;

Indexed as

BONE TURNOVERFIBROBLAST GROWTH FACTOR‐23PARATHYROID HORMONEVITAMIN DWNT PATHWAY

Identifiers

PMID35509637
PMCPMC9059470
OpenAlexW4221083250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.