Evidence map›Paper›PMID 35509631›Full record

ArticleJBMR plus2022

Type VI Collagen Regulates Endochondral Ossification in the Temporomandibular Joint.

Taishi Komori, Youngmi Ji, Hai Pham, Priyam Jani, Tina M Kilts, Vardit Kram, Li Li, Marian F Young

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Taishi KomoriDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Youngmi JiDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Hai PhamDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Priyam JaniDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Tina M KiltsDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Vardit KramDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Li LiDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.
Marian F YoungDepartment of Health and Human Services Molecular Biology of Bones and Teeth Section, National Institute of Dental and Craniofacial Research, National Institutes of Health Bethesda MD USA.ORCID https://orcid.org/0000-0003-0929-8854
National Institutes of Health · US

Funding

Function Of Skeletal Matrix GenesZIADE000379 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI YOUNG, MARIAN F · 2009 to 2023
$23.6M
Genomic and Computational Biology Support for NIDCD Intramural ResearchZICDC000086 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI MORELL, ROBERT J · 2015 to 2025
$19.8M
NIDCR Annual Reports - Veterinary Resources CoreZIGDE000740 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DAVIDSON, LAUREN · 2012 to 2025
$11.7M
Imaging CoreZICDE000750 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI DOYLE, ANDREW · 2019 to 2025
$6.9M
STRUCTURE AND BONE MATRIX GENE EXPRESSIONZ01DE000379 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI YOUNG, MARIAN F · 1985 to 2008
$2.5M
Intramural NIH HHS Z01 DE000379Intramural NIH HHS ZIC DC000086Intramural NIH HHS ZIC DE000750Intramural NIH HHS ZIG DE000740
6 · The paper itself

Abstract

For many years there has been a keen interest in developing regenerative treatment for temporomandibular joint-osteoarthritis (TMJ-OA). Currently, there is no consensus treatment due to the limited self-healing ability of articular cartilage and lack of understanding of the complex mechanisms regulating cartilage development in the TMJ. Endochondral ossification, the process of subchondral bone formation through chondrocyte differentiation, is critical for TMJ growth and development, and is tightly regulated by the composition of the extracellular matrix (ECM). Type VI collagen is a highly expressed ECM component in the TMJ cartilage, yet its specific functions are largely unknown. In this study, we investigated α2(VI)-deficient (

Indexed as

BONE MATRIXCHONDROCYTE AND CARTILAGE BIOLOGYGENETIC ANIMAL MODELSMOLECULAR PATHWAYS‐DEVELOPMENTOSTEOARTHRITIS

Identifiers

PMID35509631
PMCPMC9059467
OpenAlexW4214652566

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.