Evidence map›Paper›PMID 35509523›Full record

ReviewJournal of toxicology2022

Review of Cyanotoxicity Studies Based on Cell Cultures.

Iliyana Sazdova, Milena Keremidarska-Markova, Mariela Chichova, Blagoy Uzunov, Georgi Nikolaev, Mitko Mladenov, Rudolf Schubert, Maya Stoyneva-Gärtner, Hristo S Gagov

Open access · goldAbstract readReview
In one paragraph

Review in Journal of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Nutritional Management of Thyroiditis of Hashimoto.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Iliyana SazdovaDepartment of Animal and Human Physiology, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd., Sofia 1164, Bulgaria.ORCID https://orcid.org/0000-0002-6848-5513
Milena Keremidarska-MarkovaDepartment of Animal and Human Physiology, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd., Sofia 1164, Bulgaria.ORCID https://orcid.org/0000-0001-9385-6593
Mariela ChichovaDepartment of Animal and Human Physiology, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd., Sofia 1164, Bulgaria.ORCID https://orcid.org/0000-0002-4927-2619
Blagoy UzunovDepartment of Botany, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd. 1164 Sofia, Bulgaria.ORCID https://orcid.org/0000-0002-2285-8935
Georgi NikolaevDepartment of Cytology, Histology and Embryology, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd, Sofia 1164, Bulgaria.ORCID https://orcid.org/0000-0003-0584-415X
Mitko MladenovFaculty of Natural Sciences and Mathematics, Institute of Biology, Sts, Cyril and Methodius University, Skopje 1000, North Macedonia.ORCID https://orcid.org/0000-0003-3475-2131
Rudolf SchubertDepartment of Physiology, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg, Augsburg 86159, Germany.ORCID https://orcid.org/0000-0003-1777-1461
Maya Stoyneva-GärtnerDepartment of Botany, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd. 1164 Sofia, Bulgaria.ORCID https://orcid.org/0000-0003-2439-3737
Hristo S GagovDepartment of Animal and Human Physiology, Faculty of Biology, St. Kliment Ohridski University of Sofia, 8 Dragan Tsankov Blvd., Sofia 1164, Bulgaria.ORCID https://orcid.org/0000-0002-2759-7981
Sofia University "St. Kliment Ohridski" · BGSs. Cyril and Methodius University in Skopje · MKUniversity of Augsburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyanotoxins (CTs) are a large and diverse group of toxins produced by the peculiar photosynthetic prokaryotes of the domain Cyanoprokaryota. Toxin-producing aquatic cyanoprokaryotes can develop in mass, causing "water blooms" or "cyanoblooms," which may lead to environmental disaster-water poisoning, extinction of aquatic life, and even to human death. CT studies on single cells and cells in culture are an important stage of toxicological studies with increasing impact for their further use for scientific and clinical purposes, and for policies of environmental protection. The higher cost of animal use and continuous resistance to the use of animals for scientific and toxicological studies lead to a progressive increase of cell lines use. This review aims to present (1) the important results of the effects of CT on human and animal cell lines, (2) the methods and concentrations used to obtain these results, (3) the studied cell lines and their tissues of origin, and (4) the intracellular targets of CT. CTs reviewed are presented in alphabetical order as follows: aeruginosins, anatoxins, BMAA (

Identifiers

PMID35509523
PMCPMC9061046
OpenAlexW4224326244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.