ArticleClinical epidemiology2022
Development and Validation of a Nordic Multimorbidity Index Based on Hospital Diagnoses and Filled Prescriptions.
Article in Clinical epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Socioeconomic differences in labour market attachment after breast cancer: a population-based matched cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Association of multimorbidity with mortality risk in Chinese senior adults: a population-based cohort study.BMC geriatrics · 2026Article
- Individual and combined effects of somatic and mental disorders on reoperation risk after hip fracture surgery: a nationwide danish cohort study of 110,625 patients.European geriatric medicine · 2026Article
- General practice consultation patterns and patient factors predicting older patients' use of out-of-hours services: a nationwide register-based cohort study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2026Article
- Comorbidity indices in observational studies on cancer risk.Acta oncologica (Stockholm, Sweden) · 2026Article
- Social inequality in mental disorder diagnoses and psychotropic medication use among 15-year-old adolescents in Denmark from 2002-2022.Social psychiatry and psychiatric epidemiology · 2026Article
- Predicting avoidant coping in individuals recently diagnosed with serious illness: a cross-sectional study.Frontiers in psychology · 2026Article
- Cardiac rehabilitation in atrial fibrillation: a protocol for a Danish survey and registry-based study (PRIME-AF).BMJ open · 2025Article
- Liver Metastases and Survival Among Patients With Colorectal Cancer.JAMA network open · 2025Article
- Patient Characteristics, Healthcare Contacts and Drug Use in Polycythaemia Vera in Denmark.European journal of haematology · 2025Article
- Cardiotoxicity in patients with acute myeloid leukaemia following anthracycline-containing chemotherapy: A population-based matched cohort study.British journal of haematology · 2025Article
- Temporal trends in incidence and mortality of colorectal cancer in Denmark from 2007 to 2022.International journal of cancer · 2025Article
- Use of Potentially Inappropriate Medications Identified by STOPPFrail Among Danish Care Home Residents: A Nationwide Drug Utilisation Study.Basic & clinical pharmacology & toxicology · 2025Article
- Polypharmacy's Association With Mortality: Confounding From Underlying Morbidity.Journal of the American Geriatrics Society · 2025Article
- Polypharmacy independently predicts survival, hospitalization, and infections in patients with lymphoid cancer.HemaSphere · 2025Article
- Developmental trajectories in mental health through adolescence and adulthood: does socio-economic status matter?Epidemiology and psychiatric sciences · 2025Article
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18 authors.
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Abstract
Purpose: To develop the Nordic Multimorbidity Index (NMI), a multimorbidity measure specifically suited to the Nordic health and administrative registry data based on current diagnosis, treatment, and coding practices. Methods: The NMI was developed to predict 5-year mortality in a population-based cohort of randomly sampled Danish residents aged ≥40 years (n = 425,087) followed from 2013 to 2018. Included predictors were selected from hospital diagnoses and filled drug prescriptions based on a combination of subject matter knowledge and a data-driven approach using backwards elimination. The performance of the NMI was assessed in a temporal validation cohort of Danish residents followed from 2007 to 2012 and in six cohorts of new users of selected drugs. The discriminative performance of the NMI, Charlson Comorbidity Index (CCI) and the Elixhauser Comorbidity Index (ECI) was assessed using the c-statistic from logistic regression models with 5-year mortality as dependent variable and the multimorbidity index score, age, and sex as independent variables. Results: The NMI included 50 predictors. In the temporal validation cohort, the c-statistic of the NMI (0.887, 95% CI 0.883-0.890) exceeded that of the CCI (0.871, 95% CI 0.868-0.874) and ECI (0.866, 95% CI 0.863-0.870). In all new user cohorts, the NMI outperformed the other indices with c-statistics ranging from 0.781 (95% CI 0.779-0.784) to 0.838 (95% CI 0.834-0.842). Conclusion: The NMI predicted 5-year mortality in a general Danish population and six cohorts of new users of selected drugs and was superior to the CCI and ECI. The NMI could be preferred over these indices to quantify the level of multimorbidity for, eg, descriptive purposes or confounding control. The NMI should be validated in other patient populations and other Nordic countries.
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