Evidence map›Paper›PMID 35509471›Full record

ArticleChemical science2022

Electrostatic

Margaret L Kelty, Andrew J McNeece, Josh W Kurutz, Alexander S Filatov, John S Anderson

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Margaret L KeltyDepartment of Chemistry, University of Chicago 929 E 57th St Chicago IL 60637 USA jsanderson@uchicago.edu.
Andrew J McNeeceDepartment of Chemistry, University of Chicago 929 E 57th St Chicago IL 60637 USA jsanderson@uchicago.edu.
Josh W KurutzDepartment of Chemistry, University of Chicago 929 E 57th St Chicago IL 60637 USA jsanderson@uchicago.edu.ORCID https://orcid.org/0000-0002-3566-0514
Alexander S FilatovDepartment of Chemistry, University of Chicago 929 E 57th St Chicago IL 60637 USA jsanderson@uchicago.edu.ORCID https://orcid.org/0000-0002-8378-1994
John S AndersonDepartment of Chemistry, University of Chicago 929 E 57th St Chicago IL 60637 USA jsanderson@uchicago.edu.ORCID https://orcid.org/0000-0002-0730-3018
University of Chicago · US

Funding

Equipment Supplement: Distal Anion Stabilization of Biologically Relevant Oxo IntermediatesR35GM133470 · NIGMS · UNIVERSITY OF CHICAGO · PI ANDERSON, JOHN STUART · 2019 to 2023
$2.1M
NIGMS NIH HHS R35 GM133470
6 · The paper itself

Abstract

Enhanced rates and selectivity in enzymes are enabled in part by precisely tuned electric fields within active sites. Analogously, the use of charged groups to leverage electrostatics in molecular systems is a promising strategy to tune reactivity. However, separation of the through space and through bond effects of charged functional groups is a long standing challenge that limits the rational application of electric fields in molecular systems. To address this challenge we developed a method using the phosphorus selenium coupling value (

Identifiers

PMID35509471
PMCPMC9007067
OpenAlexW4226312052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.