ReviewTherapeutic advances in gastroenterology2022
Antireflux mucosal intervention (ARMI) procedures for refractory gastroesophageal reflux disease: a systematic review and meta-analysis.
Review in Therapeutic advances in gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Pooled it
- Antireflux mucosectomy for gastroesophageal reflux disease: efficacy and the mechanism of action.Endoscopy · 2024Trial
- Clinical Utility of Anti-reflux Mucosal Intervention for Refractory Gastroesophageal Reflux Disease in Patients With a Hiatal Hernia.DEN open · 2027Article
- Efficacy and Safety of Closure-Focused Anti-Reflux Mucoplasty Compared With Conventional ARMS: A Propensity Score-Matched Study (With Video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Article
- A pilot study on anti-reflux mucoplasty with valve as novel endoscopic therapy for gastroesophageal reflux disease.DEN open · 2026Article
- Targeted Endoscopic Therapies for Gastro-Esophageal Reflux Disease (GERD): A Narrative Review.Journal of personalized medicine · 2026Review
- Article
- Peroral Endoscopic Cardial Constriction with Band Ligation for Gastroesophageal Reflux Disease: A Prospective Pilot Study.Endoscopy international open · 2026Article
- Antireflux mucosectomy in the management of gastroesophageal reflux disease with large hiatal hernia.Endoscopy · 2025Article
- Severe adverse effect of antireflux band mucosectomy.Endoscopy · 2025Article
- Application status of endoscopic anti-reflux mucosal interventions in the treatment of gastroesophageal reflux disease.World journal of gastrointestinal surgery · 2025Review
- Current pharmacological and procedural treatments for gastro-oesophageal reflux disease: comprehensive review.BJS open · 2025Review
- A comparative analysis of ARMS (anti-reflux mucosectomy) and TIF (transoral incisionless fundoplication) in the treatment of gastroesophageal reflux disease (GERD).Annals of medicine and surgery (2012) · 2025Review
- Effect of Anti-reflux Mucosal Ablation on Esophageal Motility in Patients With Gastroesophageal Reflux Disease: A Study Based on High-resolution Impedance Manometry.Journal of neurogastroenterology and motility · 2025Article
- New Approaches and Old Struggles in Antireflux Endoscopy.Gastroenterology & hepatology · 2025Article
- Introducing antireflux mucoplasty with valve: a novel endoscopic treatment for GERD.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Antireflux mucosectomy as an effective treatment for GERD after laparoscopic sleeve gastrectomy.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Closure in antireflux mucoplasty using anchor prong clips: dead space-eliminating technique.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
- Pilot study on anti-reflux mucoplasty: Advancing endoscopic anti-reflux therapy for gastroesophageal reflux disease.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024Article
- Enhancing closure efficacy in antireflux mucoplasty through endoscopic hand-suturing technique.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endoscopic treatments are increasingly being offered for refractory gastroesophageal reflux disease (GERD). Three procedures have similar concepts and techniques: antireflux mucosectomy (ARMS), antireflux mucosal ablation (ARMA), and antireflux band ligation (ARBL); we have collectively termed them antireflux mucosal intervention (ARMI). Here, we systematically reviewed the clinical outcomes and technical aspects. Methods: The PubMed, Embase, and Cochrane Library databases were searched from inception to October 2021. The primary outcome was the clinical success rate. The secondary outcomes were acid exposure time, DeMeester score, need for proton pump inhibitors (PPIs), endoscopic findings, and adverse events. Results: Fifteen studies were included. The pooled clinical success rate was 73.8% (95% confidence interval (CI) = 69%-78%) overall, 68.6% (95% CI = 62.2%-74.4%) with ARMS, 86.7% (95% CI = 78.7%-91.9%) with ARMA, and 76.5% (95% CI = 65%-85.1%) with ARBL. ARMI resulted in significantly improved acid exposure time, DeMeester score, and degree of hiatal hernia. Furthermore, 10% of patients had dysphagia requiring endoscopic dilatation after ARMS or ARMA, and ARMS was associated with a 2.2% perforation rate. By contrast, no bleeding, perforation, or severe dysphagia was noted with ARBL. Severe hiatal hernia (Hill grade III) may predict treatment failure with ARMA. Conclusions: The three ARMI procedures were efficacious and safe for PPI-refractory GERD. ARMA and ARBL may be preferred over ARMS because of fewer adverse events and similar efficacy. Further studies are necessary to determine the optimal technique and patient selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.