ReviewJournal of neuroendocrinology2022
The ins and outs of the caudal nucleus of the solitary tract: An overview of cellular populations and anatomical connections.
Review in Journal of neuroendocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Transcutaneous vagus nerve stimulation and exercise-induced autonomic regulation: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Pooled it
- The impact of transcutaneous vagus nerve stimulation on anterior cingulate cortex activity in a cognitive control task.Psychophysiology · 2025Trial
- Molecular changes in hypoxia-induced central neural circuits and nuclei.Medical gas research · 2026Review
- A Gut-Brain Axis Underlying Succinate-Associated Compulsive-Like Behavior.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Vagus nerve stimulation in rheumatic diseases: linking autonomic nervous system regulation, inflammation, and clinical outcomes.Rheumatology international · 2026Review
- Mechanisms of Different Brainstem Nuclei Involved in Electroacupuncture-Induced Analgesia.Chinese journal of integrative medicine · 2026Review
- Acupuncture for Poststroke Dysphagia: An NTS-Centered Hypothesis-Generating Framework Linking the Brainstem Swallowing Network, Neuroimmune Regulation, and Vagal Anti-Inflammatory Signaling.Brain and behavior · 2026Review
- Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken.Poultry science · 2026Article
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- NTS Neural Subtypes and Satiety Pathways: taVNS as a Novel Neuromodulatory Intervention.Brain sciences · 2026Review
- Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.Metabolic brain disease · 2026Review
- A brainstem pathway underlying vagal modulation of somatic pain and affective states.Nature neuroscience · 2026Article
- Optogenetic activation of liver-innervating vagal sensory neurons increases anxiety-like behavior in mice.Translational psychiatry · 2026Article
- Dexpramipexole alleviates chronic allodynia from sciatic neuropathy and reduces spinal interferon-γ and other proinflammatory cytokines in spinal cord and dorsal root ganglia in mice.Medical research archives · 2026Article
- Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026Review
- Pulsed taVNS-Elicited Pupil Dilation: Effects of Intermixed Stimulation, Sham Location, and Respiratory Phase.Psychophysiology · 2026Article
- Pharmacological administration of FGF21 reverses obesity through a parabrachial-projecting neuron population in the hindbrain.Cell reports · 2026Article
- Electroacupuncture-based vagal stimulation attenuates epileptic seizures through a body-brain circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microglia alter autonomic nucleus neuronal activation after peripheral cytokine challenge.American journal of physiology. Cell physiology · 2026Article
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The body and brain are in constant two-way communication. Driving this communication is a region in the lower brainstem: the dorsal vagal complex. Within the dorsal vagal complex, the caudal nucleus of the solitary tract (cNTS) is a major first stop for incoming information from the body to the brain carried by the vagus nerve. The anatomy of this region makes it ideally positioned to respond to signals of change in both emotional and bodily states. In turn, the cNTS controls the activity of regions throughout the brain that are involved in the control of both behaviour and physiology. This review is intended to help anyone with an interest in the cNTS. First, I provide an overview of the architecture of the cNTS and outline the wide range of neurotransmitters expressed in subsets of neurons in the cNTS. Next, in detail, I discuss the known inputs and outputs of the cNTS and briefly highlight what is known regarding the neurochemical makeup and function of those connections. Then, I discuss one group of cNTS neurons: glucagon-like peptide-1 (GLP-1)-expressing neurons. GLP-1 neurons serve as a good example of a group of cNTS neurons, which receive input from varied sources and have the ability to modulate both behaviour and physiology. Finally, I consider what we might learn about other cNTS neurons from our study of GLP-1 neurons and why it is important to remember that the manipulation of molecularly defined subsets of cNTS neurons is likely to affect physiology and behaviours beyond those monitored in individual experiments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.