ArticleEBioMedicine2022
Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure.
Article in EBioMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed.
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- The Roles of Delayed Cortical Maturation and Lower Anticipatory Reward Activation in Predicting Addictive Screen Use in Youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization.PLoS computational biology · 2026Article
- A decade of discovery: Leveraging genomic data in the ABCD study to illuminate adolescent neurodevelopment.Developmental cognitive neuroscience · 2026Review
- What we have learned about adolescent mental health and where we are going after a decade with the Adolescent Brain Cognitive Development Study.Developmental cognitive neuroscience · 2026Review
- Screen time in preschool-aged children and attention deficit hyperactivity disorder-related behaviors: A literature review.World journal of clinical pediatrics · 2026Review
- Digital Media, Genetics, and Risk for ADHD Symptoms in Children: A Longitudinal Study.Pediatrics open science · 2026Article
- Screen time is a predictor of cognitive function in children with attention deficit hyperactivity disorder.Pediatric research · 2025Article
- Association of screen time with attention-deficit/hyperactivity disorder symptoms and their development: the mediating role of brain structure.Translational psychiatry · 2025Article
- Genome-wide analysis of screen behaviors among adolescents identifies novel loci and overlap with educational attainment and mental disorders.Scientific reports · 2025Article
- Parental psychopathology, family conflict, brain function, and child autistic-like traits in early adolescents.Psychological medicine · 2025Article
- Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.Neuroscience bulletin · 2025Article
- Analysing Digital Engagement Patterns: A Machine Learning Investigation into Social Anxiety Among Adolescents with ADHD.Journal of clinical medicine · 2024Article
- A phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations.Nature. Mental health · 2024Article
- Mediating pathways between attention deficit hyperactivity disorder and type 2 diabetes mellitus: evidence from a two-step and multivariable Mendelian randomization study.Epidemiology and psychiatric sciences · 2024Article
- Causal Relationships Between Screen Use, Reading, and Brain Development in Early Adolescents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The mediating effects of mobile phone use on ADHD and educational outcomes: a two-step Mendelian randomisation study.Frontiers in psychiatry · 2024Article
- Article
- Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Commentary: Relationships between screen time and childhood attention deficit hyperactivity disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
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8 authors.
Funding
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) has been reported to be associated with longer screen time utilization (STU) at the behavioral level. However, whether there are shared neural links between ADHD symptoms and prolonged STU is not clear and has not been explored in a single large-scale dataset.
methodsLeveraging the genetics, neuroimaging and behavioral data of 11,000+ children aged 9-11 from the Adolescent Brain Cognitive Development cohort, this study investigates the associations between the polygenic risk and trait for ADHD, STU, and white matter microstructure through cross-sectionally and longitudinal analyses.
findingsChildren with higher polygenic risk scores for ADHD tend to have longer STU and more severe ADHD symptoms. Fractional anisotropy (FA) values in several white matter tracts are negatively correlated with both the ADHD polygenic risk score and STU, including the inferior frontal-striatal tract, inferior frontal-occipital fasciculus, superior longitudinal fasciculus and corpus callosum. Most of these tracts are linked to visual-related functions. Longitudinal analyses indicate a directional effect of white matter microstructure on the ADHD scale, and a bi-directional effect between the ADHD scale and STU. Furthermore, reduction of FA in several white matter tracts mediates the association between the ADHD polygenic risk score and STU.
interpretationThese findings shed new light on the shared neural overlaps between ADHD symptoms and prolonged STU, and provide evidence that the polygenic risk for ADHD is related, via white matter microstructure and the ADHD trait, to STU.
fundingThis study was mainly supported by NSFC and National Key R&D Program of China.
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