Evidence map›Paper›PMID 35509105›Full record

ArticleBMC research notes2022

Oroxylin A shows limited antiviral activity towards dengue virus.

Thippayawan Ratanakomol, Sittiruk Roytrakul, Nitwara Wikan, Duncan R Smith

Open access · goldAbstract read
In one paragraph

Article in BMC research notes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Oroxylin A FromCanadian respiratory journal · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Thippayawan RatanakomolInstitute of Molecular Biosciences, Mahidol University, Salaya, 73170, Thailand.
Sittiruk RoytrakulNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani, 12120, Thailand.
Nitwara WikanInstitute of Molecular Biosciences, Mahidol University, Salaya, 73170, Thailand.
Duncan R SmithInstitute of Molecular Biosciences, Mahidol University, Salaya, 73170, Thailand. duncan_r_smith@hotmail.com.ORCID http://orcid.org/0000-0002-6592-9852
Mahidol University · THNational Science and Technology Development Agency · TH

Funding

Mahidol University NDFR 28/2564National Research Council of Thailand NRCT5-RSA63015-03Thailand Graduate Institute of Science and Technology SCA-CO-2561-6979TH
6 · The paper itself

Abstract

objectiveThe mosquito transmitted dengue virus (DENV) the causative agent of dengue fever (DF) remains a significant public health burden in many countries. Thailand, along with many countries in Asia and elsewhere, has a long history of using traditional medicines to combat febrile diseases such as DF. Screening bioactive compounds from traditional medicines reported to have antipyretic or anti-inflammatory activity may lead to the development of potent antivirals. In this study oroxylin A (OA), a flavonoid derivative found in Oroxylum indicum (commonly called the Indian trumpet flower or tree of Damocles), was screened for antiviral activity towards DENV.

resultsCytotoxicity analysis in BHK-21 cells showed a 50% cytotoxic concentration (CC

Indexed as

DengueDengue VirusAnimalsAntiviral AgentsChlorocebus aethiopsFlavonoidsThailandVero CellsVirus Replication5,7-dihydroxy-6-methoxy-2-phenylchromen-4-oneAntiviral AgentsFlavonoidsAntiviral compoundDengue virusOroxylin A

Identifiers

PMID35509105
PMCPMC9066930
OpenAlexW4229007128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.