Evidence map›Paper›PMID 35508796›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction.

Huidong Xie, Stephanie Thorn, Xiongchao Chen, Bo Zhou, Hui Liu, Zhao Liu, Supum Lee, Ge Wang, Yi-Hwa Liu, Albert J Sinusas and 1 more

Abstract read
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In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. AI in SPECT Imaging: Opportunities and Challenges.Seminars in nuclear medicine · 2025
    Review
  4. Review
  5. Unified Noise-aware Network for Low-count PET Denoising with Varying Count Levels.IEEE transactions on radiation and plasma medical sciences · 2024
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Huidong XieDepartment of Biomedical Engineering, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Stephanie ThornDepartment of Internal Medicine (Cardiology), Yale University, New Haven, CT, USA.
Xiongchao ChenDepartment of Biomedical Engineering, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Bo ZhouDepartment of Biomedical Engineering, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Hui LiuDepartment of Radiology and Biomedical Imaging, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Zhao LiuDepartment of Radiology and Biomedical Imaging, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Supum LeeDepartment of Internal Medicine (Cardiology), Yale University, New Haven, CT, USA.
Ge WangDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Yi-Hwa LiuDepartment of Internal Medicine (Cardiology), Yale University, New Haven, CT, USA.
Albert J SinusasDepartment of Biomedical Engineering, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA.
Chi LiuDepartment of Biomedical Engineering, Yale University, 801 Howard Avenue, New Haven, CT, 06520, USA. chi.liu@yale.edu.
Yale University · USNational Yang Ming Chiao Tung University · TWRensselaer Polytechnic Institute · USTsinghua University · CN

Funding

Development of advanced cardiac SPECT imaging technologiesR01HL154345 · NHLBI · YALE UNIVERSITY · PI LIU, CHI, SINUSAS, ALBERT J · 2020 to 2023
$3.2M
Hybrid Volumetric SPECT/CT Imaging SystemS10RR025555 · NCRR · YALE UNIVERSITY · PI SINUSAS, ALBERT J · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025555NHLBI NIH HHS R01 HL154345
6 · The paper itself

Abstract

backgroundThe GE Discovery NM (DNM) 530c/570c are dedicated cardiac SPECT scanners with 19 detector modules designed for stationary imaging. This study aims to incorporate additional projection angular sampling to improve reconstruction quality. A deep learning method is also proposed to generate synthetic dense-view image volumes from few-view counterparts.

methodsBy moving the detector array, a total of four projection angle sets were acquired and combined for image reconstructions. A deep neural network is proposed to generate synthetic four-angle images with 76 ([Formula: see text]) projections from corresponding one-angle images with 19 projections. Simulated data, pig, physical phantom, and human studies were used for network training and evaluation. Reconstruction results were quantitatively evaluated using representative image metrics. The myocardial perfusion defect size of different subjects was quantified using an FDA-cleared clinical software.

resultsMulti-angle reconstructions and network results have higher image resolution, improved uniformity on normal myocardium, more accurate defect quantification, and superior quantitative values on all the testing data. As validated against cardiac catheterization and diagnostic results, deep learning results showed improved image quality with better defect contrast on human studies.

conclusionIncreasing angular sampling can substantially improve image quality on DNM, and deep learning can be implemented to improve reconstruction quality in case of stationary imaging.

Indexed as

Deep LearningAnimalsHumansImage Processing, Computer-AssistedPhantoms, ImagingSwineTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedCardiac SPECTCardiovascular diseaseDeep learningFew-view imagingGE discovery NM 530c/570c

Identifiers

PMID35508796
OpenAlexW4229010658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.