Evidence map›Paper›PMID 35508697›Full record

Observational studyClinical genetics2022

Genetic clinicians' confidence in BOADICEA comprehensive breast cancer risk estimates and counselees' psychosocial outcomes: A prospective study.

Anne Brédart, Antoine De Pauw, Anja Tüchler, Inge M M Lakeman, Amélie Anota, Kerstin Rhiem, Rita Schmutzler, Christi J van Asperen, Peter Devilee, Dominique Stoppa-Lyonnet and 2 more

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04145817 (Clinical Application of the European Horizon 2020 Research Project "BRIDGES" - Study of the Psychological Impact of Breast Cancer Risk Communication in Cancer Genetics Based on the Personalized Estimation of the BOADICEA V5/PLUS Model), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04145817 nacompletednot on this map

Clinical Application of the European Horizon 2020 Research Project "BRIDGES" - Study of the Psychological Impact of Breast Cancer Risk Communication in Cancer Genetics Based on the Personalized Estimation of the BOADICEA V5/PLUS Model

TypeinterventionalSponsorInstitut CurieRan2019 to 2022Enrolled405ConditionsGenetic Predisposition to DiseaseArmsBRIDGES gene panel testing, Breast cancer risk polygenic risk score (PRS), Questionnaires
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Anne BrédartInstitut Curie, Supportive Care Department, Psycho-oncology Unit, PSL University, Paris, France.
Antoine De PauwInstitut Curie, Cancer genetic clinic, PSL University, University of Paris, Paris Cedex 05, France.
Anja TüchlerFaculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.ORCID 0000-0001-9985-8397
Inge M M LakemanDepartment of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Amélie AnotaDepartment of Clinical Research and Innovation, Centre Léon Bérard, Lyon, France.
Kerstin RhiemFaculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Rita SchmutzlerFaculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Peter DevileeDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Dominique Stoppa-LyonnetInstitut Curie, Cancer genetic clinic, PSL University, University of Paris, Paris Cedex 05, France.
Jean-Luc Kop2LPN, Université de Lorraine, Nancy, France.ORCID 0000-0002-6963-8411
Sylvie DolbeaultInstitut Curie, Supportive Care Department, Psycho-oncology Unit, PSL University, Paris, France.
Université Paris Cité · FRUniversity of Cologne · DELeiden University · NLCentre Léon Bérard · FRInserm · FRLaboratoire lorrain de psychologie et neurosciences de la dynamique des comportementsLeiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Counseling for familial breast cancer focuses on communicating the gene test result (GENE) to counselees, but risk prediction models have become more complex by including non-genetic risk factors (NGRF) and polygenic risk scores (PRS). We examined genetic clinicians' confidence in counseling and counselees' psychosocial outcomes, using the BOADICEA risk prediction tool with different categories of risk factors as input. A prospective observational study in Dutch, French and German genetic clinics was performed including 22 clinicians, and 406 of 460 (88.3%) eligible cancer-unaffected women at high breast cancer risk assessed at pre-test and 350 (76.1%) at post-test. We performed multilevel analyses accounting for the clinician, and counselees' characteristics. Overall, risk estimates category by GENE versus GENE+ NGRF, or GENE+NGRF+PRS differed in 11% and 25% of counselees, respectively. In multilevel analyses, clinicians felt less confident in counseling when the full model provided lower breast cancer risks than GENE (i.e., in 8% of cases). Older counselees expressed higher breast cancer risk perception and worries about the hereditary predisposition when the full model provided higher breast cancer risks than GENE only. Genetic clinicians appear confident with breast cancer risk comprehensive models, which seem only to affect perceptions of older counselees.

Indexed as

Breast NeoplasmsGenetic CounselingFemaleGenetic Predisposition to DiseaseHumansProspective StudiesSurveys and QuestionnairesBOADICEAbreast cancer risk estimatesgenetic-specific psychosocial difficultiesrisk communicationself-confidence

Identifiers

PMID35508697
PMCPMC9322298
OpenAlexW4229030079

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.