Evidence map›Paper›PMID 35508671›Full record

ReviewSeminars in immunopathology2022

Cell death in development, maintenance, and diseases of the nervous system.

Maria E Mercau, Siraj Patwa, Krishna P L Bhat, Sourav Ghosh, Carla V Rothlin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Maria E MercauDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6971-8676
Siraj PatwaDepartment of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA.
Krishna P L BhatDepartment of Translational Molecular Pathology, Division of Pathology-Lab Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sourav Ghosh *Department of Neurology, School of Medicine, Yale University, New Haven, CT, USA.
Carla V Rothlin *Department of Immunobiology, School of Medicine, Yale University, New Haven, CT, USA. carla.rothlin@yale.edu.ORCID http://orcid.org/0000-0002-5693-5572
Yale University · USThe University of Texas MD Anderson Cancer Center · US

Funding

An innate immune checkpoint in cancer immunotherapy.R01CA212376 · NCI · YALE UNIVERSITY · PI GHOSH, SOURAV, ROTHLIN, CARLA · 2017 to 2021
$3.1M
NCI NIH HHS 5R01CA212376
6 · The paper itself

Abstract

Cell death, be it of neurons or glial cells, marks the development of the nervous system. Albeit relatively less so than in tissues such as the gut, cell death is also a feature of nervous system homeostasis-especially in context of adult neurogenesis. Finally, cell death is commonplace in acute brain injuries, chronic neurodegenerative diseases, and in some central nervous system tumors such as glioblastoma. Recent studies are enumerating the various molecular modalities involved in the execution of cells. Intimately linked with cell death are mechanisms of disposal that remove the dead cell and bring about a tissue-level response. Heretofore, the association between these methods of dying and physiological or pathological responses has remained nebulous. It is envisioned that careful cartography of death and disposal may reveal novel understandings of disease states and chart new therapeutic strategies in the near future.

Indexed as

Nervous SystemNeurogenesisAdultCell DeathHomeostasisHumansNeuronsCell deathNervous systemPhagocytes

Identifiers

PMID35508671
OpenAlexW4229057528

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.