Evidence map›Paper›PMID 35508660›Full record

ArticleNature2022

Gene regulation by gonadal hormone receptors underlies brain sex differences.

B Gegenhuber, M V Wu, R Bronstein, J Tollkuhn

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 1 synthesis or guideline pooled it, 222 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. The neural control of infanticide and parental behaviors in male mice.bioRxiv : the preprint server for biology · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

B GegenhuberCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
M V WuCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-5246-2659
R BronsteinCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
J TollkuhnCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. tollkuhn@cshl.edu.ORCID http://orcid.org/0000-0001-5991-7620
Cold Spring Harbor Laboratory · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
Epigenetic Regulation of Sex Differences in the BrainR01MH113628 · NIMH · COLD SPRING HARBOR LABORATORY · PI Jessica Tollkuhn · 2018 to 2026
$4.8M
CSHL Watson School of Biological SciencesT32GM065094 · NIGMS · COLD SPRING HARBOR LABORATORY · PI GANN, ALEXANDER · 2002 to 2021
$4.8M
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
Estrogen receptor regulation of brain sexual differentiationF31MH124365 · NIMH · COLD SPRING HARBOR LABORATORY · PI GEGENHUBER, JORDAN BRUNO · 2020 to 2021
$57k
NCI NIH HHS P30 CA045508NIGMS NIH HHS T32 GM065094NIH HHS S10 OD028632NIMH NIH HHS F31 MH124365NIMH NIH HHS R01 MH113628
6 · The paper itself

Abstract

Oestradiol establishes neural sex differences in many vertebrates

Indexed as

BrainEstrogen Receptor alphaGene Expression RegulationSex CharacteristicsAnimalsEstradiolFemaleMaleMiceEstradiolEstrogen Receptor alpha

Identifiers

PMID35508660
PMCPMC9159952
OpenAlexW4229007424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.