ArticleNature2022
CDC7-independent G1/S transition revealed by targeted protein degradation.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 91 citations in OpenAlex.
- An updated view on lagging strand DNA replication: implications for the replication stress response.Cell cycle (Georgetown, Tex.) · 2026Article
- The dual immune landscape of homologous recombination-deficient tumors: mechanisms and therapeutic implications.Cancer metastasis reviews · 2026Review
- Cyclins and Cyclin-Dependent Kinases: Structure, Biological Functions, and Innovative Targeting Strategies in Cancer.MedComm · 2026Review
- CDC7 and APC/CNature communications · 2026Article
- Exploring the multifaceted Dbf4-dependent kinase from temporal, spatial, and substrate repertoire perspectives.Communications biology · 2026Review
- EBNA1 inhibitors reveal CDC7 and POU2F1 as direct functional targets in EBV epithelial cancers.mBio · 2026Article
- Two fork protection complexes at the replication fork play distinct roles in fork progression and stress response.Research square · 2026Article
- Adaptive Replication Fork Acceleration by CDK1-Cyclin B1 Sustains Genome Duplication despite Impaired Origin Firing.bioRxiv : the preprint server for biology · 2026Article
- Cell type-specific spatiotemporal control of GFP-tagged protein degradation in mice.The Journal of cell biology · 2026Article
- OCT4 enhances the firing efficiency of late DNA replication origins in mouse embryonic stem cells.Nature communications · 2026Article
- A new model for coordinating the functions of TIMELESS at the replication fork.bioRxiv : the preprint server for biology · 2025Article
- TheAnimals : an open access journal from MDPI · 2025Article
- Inactivation of CDK4/6, CDK2, and ERK in G1-phase triggers differentiation commitment.Communications biology · 2025Article
- STPath: a generative foundation model for integrating spatial transcriptomics and whole-slide images.NPJ digital medicine · 2025Article
- GmCDC7 is involved in coordinating seed size and quality in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics.Nature communications · 2025Article
- Tissue-specific consequences of tag fusions on protein expression in transgenic mice.PLoS genetics · 2025Article
- Hepatitis B virus core/capsid protein induces hepatocellular carcinoma progression via long non-coding RNA KCNQ1OT1/miR-335-5p/CDC7 axis.Translational cancer research · 2025Article
- An auxin-inducible degron system for conditional mutation in the fungal meningitis pathogen Cryptococcus neoformans.G3 (Bethesda, Md.) · 2025Article
- AZIN1-dependent polyamine synthesis accelerates tumor cell cycle progression and impairs effector T-cell function in osteosarcoma.Cell death & disease · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 2 institutions in 2 countries.
Jan M SuskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nalin RatnayekeDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
Marcin BraunDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3804-7042
Tian ZhangDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9007-7965
Vladislav StrmiskaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Wojciech MichowskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Geylani CanDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1716-7830
Antoine SimoneauMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Konrad SniochDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Mikolaj CupDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Caitlin M SullivanDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xiaoji WuDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Joanna NowackaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Timothy B BraniganDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Lindsey R PackDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA.
James A DeCaprioDepartment of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0896-167X
Yan GengDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Lee ZouMassachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA.
Steven P GygiDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7626-0034
Johannes C WalterDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4186-7570
Tobias MeyerDepartment of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY, USA. tom4003@med.cornell.edu.ORCID http://orcid.org/0000-0003-4339-3804
Piotr SicinskiDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. peter_sicinski@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-8859-5234
Harvard University · USCornell University · US
Funding
Tissue and Pathology CoreP01CA250959 · NCI · DANA-FARBER CANCER INST · PI POLYAK, KORNELIA · 2020 to 2024
$8.6MCell Signaling and Cell DecisionsR35GM127026 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TOBIAS MEYER · 2018 to 2026
$8.5MThe Fanconi anemia pathway: role in DNA interstrand cross-link repairR01HL098316 · NHLBI · HARVARD MEDICAL SCHOOL · PI Johannes Walter · 2010 to 2026
$6.3MCDC7 kinase in normal and cancer cells: potential implications for cancer treatmentR01CA247375 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2020 to 2024
$2.3MNovel functions of D-type and E-type cyclins in normal and in cancer cellsR01CA202634 · NCI · DANA-FARBER CANCER INST · PI SICINSKI, PETER · 2016 to 2020
$2.1MFunctions of Cyclin/CDK complexes in development and cancerR50CA243769 · NCI · DANA-FARBER CANCER INST · PI GENG, YAN · 2019 to 2023
$898kCancer Research UK 30783NCI NIH HHS P01 CA250959NCI NIH HHS R01 CA202634NCI NIH HHS R01 CA247375NCI NIH HHS R50 CA243769NHLBI NIH HHS R01 HL098316NIGMS NIH HHS R35 GM127026
Abstract
The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key event in cell division
Indexed as
Cell Cycle ProteinsG1 PhaseProtein Serine-Threonine KinasesProteolysisS PhaseAnimalsDNA ReplicationMiceCdc7 protein, mouseCell Cycle ProteinsProtein Serine-Threonine Kinases
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.