ArticleNature communications2022
Decarboxylative tandem C-N coupling with nitroarenes via S
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
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Who cites it
18 citing papers in PubMed, 79 citations in OpenAlex.
- Reactivity of Nitroarenes toward Alkyl Radicals Enables Direct C-H Alkylation.Journal of the American Chemical Society · 2026Article
- Photochemical, electrochemical and electrophotochemical C-N bond-forming cross-coupling reactions.Nature reviews. Chemistry · 2026Review
- Cross-ketone deacylative coupling via oxidative SNature communications · 2026Article
- Three-component synthesis of β-thio tertiary alkylamines from simple alkenes via SScience advances · 2026Article
- Iron-Catalyzed Alkylation-Reduction ofOrganic letters · 2025Article
- Carbon-Heteroatom Bond Formation via Photoinduced Decarboxylative Radical Coupling Reactions.ACS omega · 2025Review
- LMCT-Driven Iron Photocatalysis: Mechanistic Insights and Synthetic Applications.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Radical Sorting Catalysis via Bimolecular Homolytic Substitution (SJournal of the American Chemical Society · 2025Review
- Unlocking Chromium Decarboxylative Ligand-to-Metal Charge Transfer: Efficient and Redox-Neutral Allylation of Aldehydes Using Carboxylic Acids.Journal of the American Chemical Society · 2025Article
- Stereoselective benzylic C(spChemical science · 2024Article
- Acridine photocatalysis enables tricomponent direct decarboxylative amine construction.Chemical science · 2024Article
- Multimodal Acridine Photocatalysis Enables Direct Access to Thiols from Carboxylic Acids and Elemental Sulfur.ACS catalysis · 2024Article
- Visible light mediated iron-catalyzed addition of oxamic acids to imines.RSC advances · 2024Article
- Article
- Kinetically-driven reactivity of sulfinylamines enables direct conversion of carboxylic acids to sulfinamides.Chemical science · 2023Article
- Article
- Radical Decarboxylative Carbon-Nitrogen Bond Formation.Molecules (Basel, Switzerland) · 2023Review
- Iron-mediated ligand-to-metal charge transfer enables 1,2-diazidation of alkenes.Nature communications · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aromatic tertiary amines are one of the most important classes of organic compounds in organic chemistry and drug discovery. It is difficult to efficiently construct tertiary amines from primary amines via classical nucleophilic substitution due to consecutive overalkylation. In this paper, we have developed a radical tandem C-N coupling strategy to efficiently construct aromatic tertiary amines from commercially available carboxylic acids and nitroarenes. A variety of aromatic tertiary amines can be furnished in good yields (up to 98%) with excellent functional group compatibility under mild reaction conditions. The use of two different carboxylic acids also allows for the concise synthesis of nonsymmetric aromatic tertiary amines in satisfactory yields. Mechanistic studies suggest the intermediacy of the arylamine-(TPP)Fe(III) species and might provide a possible evidence for an S
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.