ArticleNature communications2022
Dichotomy of the BSL phosphatase signaling spatially regulates MAPK components in stomatal fate determination.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- HDACi induces apoptosis of osteosarcoma cells by inhibiting the MAPK pathway.Scientific reports · 2026Article
- A Dual-Receptor System MediatesJournal of agricultural and food chemistry · 2026Article
- CLE19 suppresses brassinosteroid signaling output via the BSL-BIN2 module to maintain BES1 activity and pollen exine patterning in Arabidopsis.Journal of integrative plant biology · 2025Article
- Mitotic entry is controlled by the plant-specific phosphatase BSL1 and cyclin-dependent kinase B.Nature plants · 2025Article
- Split-YFP-coupled interaction-dependent TurboID identifies new functions of basal cell polarity inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Guardians of Water and Gas Exchange: Adaptive Dynamics of Stomatal Development and Patterning.Plants (Basel, Switzerland) · 2025Review
- Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded WithFood science & nutrition · 2025Article
- Synergistic Inhibition of Breast Carcinoma Cell Proliferation by Quercetin and Sulforaphane via Activation of the ERK/MAPK Pathway.Cell biochemistry and biophysics · 2025Article
- Limocitrin induced cellular death through ERK pathways in human oral squamous cell cancer.Scientific reports · 2025Article
- Phosphoproteomic analysis uncovers phosphorylated proteins in response to salicylic acid and N-hydroxypipecolic acid in Arabidopsis.Molecular biology reports · 2024Article
- Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis.Current biology : CB · 2024Article
- Natural products targeting the MAPK-signaling pathway in cancer: overview.Journal of cancer research and clinical oncology · 2024Review
- Specificity models in MAPK cascade signaling.FEBS open bio · 2023Review
- Identification and validation of quantitative trait loci for fertile spikelet number per spike and grain number per fertile spikelet in bread wheat (Triticum aestivum L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Asymmetric cell division in plant development.Journal of integrative plant biology · 2023Review
- Using quantitative methods to understand leaf epidermal development.Quantitative plant biology · 2022Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
MAPK signaling modules play crucial roles in regulating numerous biological processes in all eukaryotic cells. How MAPK signaling specificity and strength are tightly controlled remains a major challenging question. In Arabidopsis stomatal development, the MAPKK Kinase YODA (YDA) functions at the cell periphery to inhibit stomatal production by activating MAPK 3 and 6 (MPK3/6) that directly phosphorylate stomatal fate-determining transcription factors for degradation in the nucleus. Recently, we demonstrated that BSL1, one of the four BSL protein phosphatases, localizes to the cell cortex to activate YDA, elevating MPK3/6 activity to suppress stomatal formation. Here, we showed that at the plasma membrane, all four members of BSL proteins contribute to the YDA activation. However, in the nucleus, specific BSL members (BSL2, BSL3, and BSU1) directly deactivate MPK6 to counteract the linear MAPK pathway, thereby promoting stomatal formation. Thus, the pivotal MAPK signaling in stomatal fate determination is spatially modulated by a signaling dichotomy of the BSL protein phosphatases in Arabidopsis, providing a prominent example of how MAPK activities are integrated and specified by signaling compartmentalization at the subcellular level.
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