ArticleNature communications2022
Transition from predictable to variable motor cortex and striatal ensemble patterning during behavioral exploration.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Conserved role of primary motor cortex in the control of prehension in mice and macaques.Cell reports · 2026Article
- Article
- Shared somatosensory-motor neural population dynamics track motor recovery after stroke.bioRxiv : the preprint server for biology · 2026Article
- Neural representation of action symbols in primate frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Fluctuation-learning relationship in recurrent neural networks.Nature communications · 2025Article
- Structure of activity in multiregion recurrent neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coupling of Slow Oscillations in the Prefrontal and Motor Cortex Predicts Onset of Spindle Trains and Persistent Memory Reactivations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Single-Trial Representations of Decision-Related Variables by Decomposed Frontal Corticostriatal Ensemble Activity.eNeuro · 2024Article
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Dissociating the contributions of sensorimotor striatum to automatic and visually guided motor sequences.Nature neuroscience · 2023Article
- Emergent Low-Frequency Activity in Cortico-Cerebellar Networks with Motor Skill Learning.eNeuro · 2023Article
- Modulation of neural co-firing to enhance network transmission and improve motor function after stroke.Neuron · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Animals can capitalize on invariance in the environment by learning and automating highly consistent actions; however, they must also remain flexible and adapt to environmental changes. It remains unclear how primary motor cortex (M1) can drive precise movements, yet also support behavioral exploration when faced with consistent errors. Using a reach-to-grasp task in rats, along with simultaneous electrophysiological monitoring in M1 and dorsolateral striatum (DLS), we find that behavioral exploration to overcome consistent task errors is closely associated with tandem increases in M1 and DLS neural variability; subsequently, consistent ensemble patterning returns with convergence to a new successful strategy. We also show that compared to reliably patterned intracranial microstimulation in M1, variable stimulation patterns result in significantly greater movement variability. Our results thus indicate that motor and striatal areas can flexibly transition between two modes, reliable neural pattern generation for automatic and precise movements versus variable neural patterning for behavioral exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.