Evidence map›Paper›PMID 35508396›Full record

ArticleNeurology2022

Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults.

May A Beydoun, Hind A Beydoun, Marie T Fanelli-Kuczmarski, Jordan Weiss, Sharmin Hossain, Jose Atilio Canas, Michele Kim Evans, Alan B Zonderman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 59 citations in OpenAlex.

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  10. Understanding mechanisms of antioxidant action in health and disease.Nature reviews. Molecular cell biology · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

May A BeydounFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Hind A BeydounFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Marie T Fanelli-KuczmarskiFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Jordan WeissFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Sharmin HossainFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Jose Atilio CanasFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Michele Kim EvansFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.ORCID 0000-0002-8546-2831
Alan B ZondermanFrom the Laboratory of Epidemiology and Population Sciences (M.A.B., S.H., M.K.E., A.B.Z.), National Institute on Aging, Intramural Research Program, NIA/NIH/IRP, Baltimore, MD; Department of Research Programs (H.A.B.), Fort Belvoir Community Hospital, VA; Department of Behavioral Health and Nutrition (M.T.F.-K.), University of Delaware, Newark; Department of Demography (J.W.), University of California, Berkeley; and Department of Pediatrics (J.A.C.), Johns Hopkins Medical Institutions, St. Petersburgh, FL.
Alexander T. Augusta Military Medical Center · US

Funding

Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS)ZIAAG000513 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$70.9M
6 · The paper itself

Abstract

BACKGROUND AND

objectivesSerum antioxidant vitamins and carotenoids may protect against neurodegeneration with age. We examined associations of these nutritional biomarkers with incident all-cause and Alzheimer disease (AD) dementia among US middle-aged and older adults.

methodsUsing data from the third National Health and Nutrition Examination Surveys (1988-1994), linked with Centers for Medicare & Medicaid follow-up data, we tested associations and interactions of serum vitamins A, C, and E and total and individual serum carotenoids and interactions with incident AD and all-cause dementia. Cox proportional hazards regression models were conducted.

resultsAfter ≤26 years follow-up (mean 16-17 years, 7,283 participants aged 45-90 years at baseline), serum lutein+zeaxanthin was associated with reduced risk of all-cause dementia (65+ age group), even in the lifestyle-adjusted model (per SD: hazard ratio [HR] 0.93, 95% CI 0.87-0.99; DISCUSSION: Incident all-cause dementia was inversely associated with serum lutein+zeaxanthin and β-cryptoxanthin levels. Further studies with time-dependent exposures and randomized trials are needed to test neuroprotective effects of supplementing the diet with select carotenoids. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that incident all-cause dementia was inversely associated with serum lutein+zeaxanthin and β-cryptoxanthin levels.

Indexed as

Alzheimer DiseaseCarotenoidsAgedAntioxidantsBeta-CryptoxanthinHumansLuteinMedicareMiddle AgedRisk FactorsUnited StatesVitaminsZeaxanthinsAntioxidantsBeta-CryptoxanthinCarotenoidsLuteinVitaminsZeaxanthins

Identifiers

PMID35508396
PMCPMC9169941
OpenAlexW4229017617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.