ArticleESC heart failure2022
Intracerebral bleeding in donors is associated with reduced short-term to midterm survival of heart transplant recipients.
Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Heart transplant survival and the use of donors with intracranial bleeding: United Network for Organ Sharing Registry propensity-score matched analysis.JTCVS open · 2024Article
- Donor Noradrenaline Support Is Not Associated with Decreased Survival in Heart Transplant Recipients.Journal of clinical medicine · 2022Article
- Intracerebral bleeding in donors is associated with reduced short-term to midterm survival of heart transplant recipients.ESC heart failure · 2022Article
- Outcome and Midterm Survival after Heart Transplantation Is Independent from Donor Length of Stay in the Intensive Care Unit.Life (Basel, Switzerland) · 2022Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe quality of the donor heart is known to have a crucial effect on outcome after heart transplantation (HTx). Although leading to brain death in the end, the initial cause of death of the donor and its potential influences on organ quality are heterogeneous. However, it is still controversial to which extent the donor cause of death is associated with outcome or survival post-HTx. METHODS AND
resultsWe included all patients undergoing HTx in our centre between September 2010 and June 2021 (n = 218). Recipients were divided in five groups related to their donor cause of death: intracerebral bleeding ('ICB', n = 95, 44%), traumatic brain injury ('trauma', n = 54, 25%), hypoxic brain damage ('hypoxic', n = 34, 16%), cerebrovascular ('vascular', n = 15, 7%), or other cause (n = 20, 9%). Baseline characteristics, perioperative parameters, and survival after 30 and 90 days as well as 5 years after transplantation were collected.
resultsIntracerebral bleeding in donors compared with traumatic brain injury is associated with higher probability of need for ECLS post-HTx (35% vs. 19%, P = 0.04) and significantly reduced survival up to 5 years post-HTx (i.e. 1 year survival: 61% vs. 95%, P < 0.0001). Although other conditions also show significant changes in outcome and survival, the effect is strongest for ICB, where survival is also reduced compared with all other causes (1 year: 61% vs. 89%, P < 0.0001).
conclusionsIn this retrospective analysis, donor cause of death is associated with differing outcome and survival after HTx. Intracerebral bleeding hereby shows strongest decline in outcome and survival in comparison with all other causes.
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