ArticleACS chemical biology2022
DRUG-seq Provides Unbiased Biological Activity Readouts for Neuroscience Drug Discovery.
Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- A scalable, high-throughput glue perturbation screening platform for molecular glue discovery.iScience · 2026Article
- A systematic transcriptomic atlas and predictive framework for metabolite-driven T cell state transitions.iScience · 2026Article
- Functional genomic profiling of schizophrenia-associated genes reveals key microglial regulators.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- ExPO: an exposure-conditioned neural operator for L1000 signature prediction.Journal of cheminformatics · 2026Article
- mTOR inhibition promotes ATRA-induced cancer cell differentiation by overcoming a metabolic hyperactive state.Journal of translational medicine · 2026Article
- Identification of a Small-Molecule Modulator of Astrocyte Reactivity for Optic Nerve Protection.Investigative ophthalmology & visual science · 2026Article
- High-throughput transcriptomic screening reveals entrectinib as a repositioning opportunity in 19q12 autism spectrum disorder.Scientific reports · 2025Article
- Expanding research and care for Leigh syndrome: efforts of a patient-led advocacy organization.Research involvement and engagement · 2025Article
- Functional Genomic Profiling of Schizophrenia-Associated Genes Reveals Key Microglial Regulators.bioRxiv : the preprint server for biology · 2025Article
- Identifying brain-penetrant small-molecule modulators of human microglia using a cellular model of synaptic pruning.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- High-throughput profiling of chemical-induced gene expression across 93,644 perturbations.Nature methods · 2025Article
- Coordinated regulation by lncRNAs results in tight lncRNA-target couplings.Cell genomics · 2025Article
- Identifying Age-Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age.Aging cell · 2025Article
- Article
- Single-cell multiomics reveals a gene regulatory circuit driving leukemia cell differentiation.Oncogene · 2025Article
- An atlas of transcriptomic changes in human immune cells driven by 364 endogenous and gut-microbiota-derived metabolites.Scientific reports · 2025Article
- AnchorDrug: A system for drug-induced gene expression prediction in new contexts through active learning.Proceedings of the ... SIAM International Conference on Data Mining. SIAM International Conference on Data Mining · 2025Article
- DRAGoN: a robust pipeline for analyzing DRUG-seq datasets.Bioinformatics advances · 2025Article
- macpie: Scalable workflow for high-throughput transcriptomic profiling.Computational and structural biotechnology journal · 2025Article
- Molecular and functional landscape of malignant serous effusions for precision oncology.Nature communications · 2024Article
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unbiased transcriptomic RNA-seq data has provided deep insights into biological processes. However, its impact in drug discovery has been narrow given high costs and low throughput. Proof-of-concept studies with Digital RNA with pertUrbation of Genes (DRUG)-seq demonstrated the potential to address this gap. We extended the DRUG-seq platform by subjecting it to rigorous testing and by adding an open-source analysis pipeline. The results demonstrate high reproducibility and ability to resolve the mechanism(s) of action for a diverse set of compounds. Furthermore, we demonstrate how this data can be incorporated into a drug discovery project aiming to develop therapeutics for schizophrenia using human stem cell-derived neurons. We identified both an on-target activation signature, induced by a set of chemically distinct positive allosteric modulators of the
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