Evidence map›Paper›PMID 35508329›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Frontal asymmetry as a core feature of major depression: a functional near-infrared spectroscopy study.

Hsiang-Jung Tseng, Chia-Feng Lu, Jia-Shyun Jeng, Chih-Ming Cheng, Jui-Wen Chu, Mu-Hong Chen, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Cheng-Ta Li

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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hsiang-Jung TsengFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Chia-Feng LuFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Jia-Shyun JengFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Chih-Ming ChengFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Jui-Wen ChuFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Mu-Hong ChenFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Ya-Mei BaiFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Shih-Jen TsaiFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Tung-Ping SuFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan.
Cheng-Ta LiFrom the Department of Psychiatry (Tseng, Jeng, Cheng, Chu, Chen, Bai, Tsai, Su, Li), Taipei Veterans General Hospital, Taipei, Taiwan; the Department of Biomedical Imaging and Radiological Sciences (Lu), National Yang Ming University, Taipei, Taiwan; the Division of Psychiatry (Cheng, Chen, Bai, Tsai, Su, Li), School of Medicine, National Yang-Ming University, Taipei, Taiwan; the Department of Psychiatry (Su), Cheng Hsin General Hospital, Taipei, Taiwan On5083@msn.com.
Cheng Hsin General Hospital · TWTaipei Veterans General Hospital · TWNational Yang Ming University Hospital · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFrontal asymmetry plays a major role in depression. However, patients with treatment-resistant depression (TRD) have widespread hypofrontality. We investigated whether patients with TRD have a characteristic frontal activation pattern in functional near-infrared spectroscopy (fNIRS) findings and how the frontal cortex responds to different levels of cognitive tasks.

methodsWe enrolled 27 right-handed patients with TRD, 27 patients without TRD and 27 healthy controls. We used multichannel fNIRS to evaluate activation of the bilateral dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC) and left motor area in response to 3 tasks: finger tapping, a low cognitive-load motor task; verbal fluency, a moderate cognitive-load task; and a dual task involving simultaneous finger tapping and verbal fluency, a high cognitive-load task.

resultsWe found significant between-group differences in left DLPFC activation for all 3 tasks. The healthy controls had cortical activation in the left motor area during finger tapping and the bilateral frontal cortex during the dual task. However, patients without TRD had right VLPFC activation during finger tapping and left DLPFC activation during the dual task. Patients with TRD had bilateral DLPFC activation during finger tapping but exhibited increased bilateral VLPFC and left motor area activation during verbal fluency and increased left motor area activation during the dual task. In healthy controls and patients without TRD, we found that the right VLPFC was positively correlated with depression severity. LIMITATIONS: Our cohort included only patients with late-onset depression.

conclusionWe found different patterns of abnormal frontal activation between patients with and without TRD. In patients without TRD, the right prefrontal cortex (PFC) was recruited during simple motor tasks. However, in patients with TRD, the bilateral PFC was recruited during simple tasks and motor cortical resources were used compensatorily during PFC-demanding complex cognitive tasks.

Indexed as

Major Depressive DisorderMotor CortexDepressionHumansPrefrontal CortexSpectroscopy, Near-Infrared

Identifiers

PMID35508329
PMCPMC9074804
OpenAlexW4225373676

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.