Evidence map›Paper›PMID 35508328›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Multimetric structural covariance in first-episode major depressive disorder: a graph theoretical analysis.

Chujun Chen, Zhening Liu, Chang Xi, Wenjian Tan, Zebin Fan, Yixin Cheng, Jun Yang, Lena Palaniyappan, Jie Yang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Chujun ChenFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Zhening LiuFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Chang XiFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Wenjian TanFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Zebin FanFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Yixin ChengFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Jun YangFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan) lena.palaniyappan@mcgill.ca yang0826@csu.edu.cn.
Lena PalaniyappanFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan) lena.palaniyappan@mcgill.ca yang0826@csu.edu.cn.
Jie YangFrom the Department of Psychiatry, Second Xiangya Hospital of Central South University, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the National Clinical Research Centre for Mental Disorders, Changsha, China (Chen, Liu, Xi, Tan, Fan, Cheng, Jun Yang, Jie Yang); the Department of Psychiatry, University of Western Ontario, London, Ont. (Palaniyappan); the Robarts Research Institute, University of Western Ontario, London, Ont. (Palaniyappan); the Lawson Health Research Institute, London, Ont. (Palaniyappan); the Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montréal, Quebec (Palaniyappan).
Central South University · CNLawson Health Research Institute · CANational Clinical Research · USWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAbnormalities of cortical morphology have been consistently reported in major depressive disorder (MDD), with widespread focal alterations in cortical thickness, surface area and gyrification. However, it is unclear whether these distributed focal changes disrupt the system-level architecture (topology) of brain morphology in MDD. If present, such a topological disruption might explain the mechanisms that underlie altered cortical morphology in MDD.

methodsSeventy-six patients with first-episode MDD (33 male, 43 female) and 66 healthy controls (32 male, 34 female) underwent structural MRI scans. We calculated cortical indices, including cortical thickness, surface area and local gyrification index, using FreeSurfer. We constructed morphological covariance networks using the 3 cortical indices separately, and we analyzed the topological properties of these group-level morphological covariance networks using graph theoretical approaches.

resultsTopological differences between patients with first-episode MDD and healthy controls were restricted to the thickness-based network. We found a significant decrease in global efficiency but an increase in local efficiency of the left superior frontal gyrus and the right paracentral lobule in patients with first-episode MDD. When we simulated targeted lesions affecting the most highly connected nodes, the thickness-based networks in patients with first-episode MDD disintegrated more rapidly than those in healthy controls. LIMITATIONS: Our sample of patients with first-episode MDD has limited generalizability to patients with chronic and recurrent MDD.

conclusionA systems-level disruption in cortical thickness (but not surface area or gyrification) occurs in patients with first-episode MDD.

Indexed as

Major Depressive DisorderBrainCerebral CortexFemaleFrontal LobeHumansMagnetic Resonance ImagingMalePrefrontal Cortex

Identifiers

PMID35508328
PMCPMC9074807
OpenAlexW4229002033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.