ArticleJournal of psychiatry & neuroscience : JPN
Peptidergic neurons of the Edinger-Westphal nucleus express TRPA1 ion channel that is downregulated both upon chronic variable mild stress in male mice and in humans who died by suicide.
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18 citing papers in PubMed, 26 citations in OpenAlex.
- Transcriptome profiling of human hypothalamic agouti-related protein and proopiomelanocortin neurons regulating energy homeostasis.Nature communications · 2026Article
- Age-dependent alterations of TRPA1 and urocortin 1 signaling in the Edinger-Westphal nucleus in a mouse model of Alzheimer's disease.Scientific reports · 2026Article
- Article
- Prokineticin 2 regulates the electrophysiological activity of gonadotropin-releasing hormone neurons via direct signalling in adult female mice.Frontiers in endocrinology · 2026Article
- Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus.Scientific reports · 2025Article
- Anxiolytic and Antidepressant Effects of Organic Polysulfide, Dimethyl Trisulfide Are Partly Mediated by the Transient Receptor Potential Ankyrin 1 Ion Channel in Mice.Pharmaceutics · 2025Article
- Propofol Promotes Anesthesia Through the Activation of Centrally-Projecting Edinger-Westphal Nucleus Urocortin 1-Positive Neurons.Neuroscience bulletin · 2025Article
- Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Examination of the Effect of Dimethyl Trisulfide in Acute Stress Mouse Model with the Potential Involvement of the TRPA1 Ion Channel.International journal of molecular sciences · 2024Article
- TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation.Biomolecules · 2024Article
- The Lack of TRPA1 Ion Channel Does Not Affect the Chronic Stress-Induced Activation of the Locus Ceruleus.International journal of molecular sciences · 2024Article
- Downregulation of PACAP and the PAC1 Receptor in the Basal Ganglia, Substantia Nigra and Centrally Projecting Edinger-Westphal Nucleus in the Rotenone model of Parkinson's Disease.International journal of molecular sciences · 2023Article
- Linking stress with urocortin in rats.Bioinformation · 2023Article
- Association between TRP channels and glutamatergic synapse gene polymorphisms and migraine and the comorbidities anxiety and depression in a Chinese population.Frontiers in genetics · 2023Article
- Fluoxetine treatment supports predictive validity of the three hit model of depression in male PACAP heterozygous mice and underpins the impact of early life adversity on therapeutic efficacy.Frontiers in endocrinology · 2022Article
- Functionally active TRPA1 ion channel is downregulated in peptidergic neurons of the Edinger-Westphal nucleus upon acute alcohol exposure.Frontiers in cell and developmental biology · 2022Article
- Transient receptor potential ankyrin 1 ion channel expressed by the Edinger-Westphal nucleus contributes to stress adaptation in murine model of posttraumatic stress disorder.Frontiers in cell and developmental biology · 2022Article
- Age-Dependent FOSB/ΔFOSB Response to Acute and Chronic Stress in the Extended Amygdala, Hypothalamic Paraventricular, Habenular, Centrally-Projecting Edinger-Westphal, and Dorsal Raphe Nuclei in Male Rats.Frontiers in aging neuroscience · 2022Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Viktória KormosFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér) viktoria.kormos@aok.pte.hu balazs.b.gaszner@aok.pte.hu.
Angéla KecskésFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
József FarkasFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Tamás GasznerFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Valér CsernusFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Ammar AlomariFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Dániel HegedüsFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Éva RennerFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Miklós PalkovitsFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Dóra ZelenaFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Zsuzsanna HelyesFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Erika PintérFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
Balázs GasznerFrom the Department of Pharmacology and Pharmacotherapy, Medical School and Molecular Pharmacology Research Group, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Kormos, Kecskés, Alomari, Hegedüs, Helyes, Pintér); the Department of Anatomy, Medical School and Research Group for Mood Disorders, Centre for Neuroscience, Szentágothai Research Centre, University of Pécs, Pécs, Hungary (Farkas, T. Gaszner, Csernus, Hegedüs, B. Gaszner); Human Brain Tissue Bank and Laboratory, Semmelweis University, Budapest, Hungary (Renner, Palkovits); the Department of Physiology, Medical School, Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Pécs, Hungary (Zelena); Pharm-InVivo Ltd., Pécs, Hungary (Helyes, Pintér).
University of Pecs · HUSemmelweis University · HU
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransient receptor potential ankyrin 1 (TRPA1), a cation channel, is expressed predominantly in primary sensory neurons, but its central distribution and role in mood control are not well understood. We investigated whether TRPA1 is expressed in the urocortin 1 (UCN1)-immunoreactive centrally projecting Edinger-Westphal nucleus (EWcp), and we hypothesized that chronic variable mild stress (CVMS) would reduce its expression in mice. We anticipated that
methodsWe exposed
resultsLIMITATIONS: Developmental compensations and the global lack of TRPA1 may have influenced our findings. Because experimental data came from male brains only, we have no evidence for whether findings would be similar in female brains. Because a TRPA1-specific antibody is lacking, we have provided mRNA data only. Limited access to high-quality human tissues restricted sample size.
conclusionTRPA1 in EWcp/UCN1 neurons might contribute to the regulation of depression-like behaviour and stress adaptation response in mice. In humans, TRPA1 might contribute to mood control via EWcp/UCN1 neurons.
Indexed as
Edinger-Westphal NucleusSuicideAnimalsFemaleHumansIon ChannelsMaleMiceMice, KnockoutNeuronsRNA, MessengerTRPA1 Cation ChannelUrocortinsIon ChannelsRNA, MessengerTRPA1 Cation ChannelTRPA1 protein, humanTrpa1 protein, mouseUrocortins
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