Evidence map›Paper›PMID 35508197›Full record

ArticleApplied clinical informatics2022

Monitoring Approaches for a Pediatric Chronic Kidney Disease Machine Learning Model.

Keith E Morse, Conner Brown, Scott Fleming, Irene Todd, Austin Powell, Alton Russell, David Scheinker, Scott M Sutherland, Jonathan Lu, Brendan Watkins and 3 more

Abstract readEvaluation Study
In one paragraph

Article in Applied clinical informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Keith E MorseDivision of Pediatric Hospital Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States.
Conner BrownInformation Services Department, Lucile Packard Children's Hospital, Stanford, Palo Alto, California, United States.
Scott FlemingDepartment of Biomedical Data Science, Stanford University, Palo Alto, California, United States.
Irene ToddInformation Services Department, Lucile Packard Children's Hospital, Stanford, Palo Alto, California, United States.
Austin PowellInformation Services Department, Lucile Packard Children's Hospital, Stanford, Palo Alto, California, United States.
Alton RussellHarvard Medical School, Boston, Massachusetts, United States.
David ScheinkerInformation Services Department, Lucile Packard Children's Hospital, Stanford, Palo Alto, California, United States.
Scott M SutherlandDivision of Nephrology, Department of Pediatrics, Stanford University, Stanford, California, United States.
Jonathan LuDepartment of Biomedical Data Science, Stanford University, Palo Alto, California, United States.
Brendan WatkinsInformation Services Department, Lucile Packard Children's Hospital, Stanford, Palo Alto, California, United States.
Nigam H ShahDepartment of Biomedical Data Science, Stanford University, Palo Alto, California, United States.
Natalie M PagelerDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California, United States.
Jonathan P PalmaDivision of Neonatology, Department of Pediatrics, Orlando Health, Orlando, Florida, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this study is to evaluate the ability of three metrics to monitor for a reduction in performance of a chronic kidney disease (CKD) model deployed at a pediatric hospital.

methodsThe CKD risk model estimates a patient's risk of developing CKD 3 to 12 months following an inpatient admission. The model was developed on a retrospective dataset of 4,879 admissions from 2014 to 2018, then run silently on 1,270 admissions from April to October, 2019. Three metrics were used to monitor its performance during the silent phase: (1) standardized mean differences (SMDs); (2) performance of a "membership model"; and (3) response distribution analysis. Observed patient outcomes for the 1,270 admissions were used to calculate prospective model performance and the ability of the three metrics to detect performance changes.

resultsThe deployed model had an area under the receiver-operator curve (AUROC) of 0.63 in the prospective evaluation, which was a significant decrease from an AUROC of 0.76 on retrospective data (

conclusionThis study suggests that the three metrics examined could provide early indication of performance deterioration in deployed models' performance.

Indexed as

Computer SimulationMachine LearningBenchmarkingChildFemaleHospitalizationHumansMaleModels, BiologicalProspective StudiesRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsROC Curve

Identifiers

PMID35508197
PMCPMC9068274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.