ArticleNeuron2022
Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- A standard model for the vertebrate retina.Vision research · 2026Article
- Article
- Intrinsic electrical diversity of PViScience · 2026Article
- Unraveling the role of asymmetric excitatory and inhibitory synaptic inputs to retinal ganglion cell direction selectivity.Frontiers in neuroscience · 2026Article
- Article
- Optic nerve injury impairs intrinsic mechanisms underlying electrical activity in a resilient retinal ganglion cell.The Journal of physiology · 2025Article
- Divergent mechanisms of neural adaptation and instability in the mammalian retina.Current biology : CB · 2025Article
- Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells.eLife · 2025Article
- Differential Intrinsic Firing Properties in Sustained and Transient Mouse αRGCs Match Their Light Response Characteristics and Persist during Retinal Degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Cell-type specific repertoire of responses to natural scenes in primate retinal ganglion cells.Frontiers in cellular neuroscience · 2025Article
- Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons.Neuron · 2024Article
- Individual thalamic inhibitory interneurons are functionally specialized toward distinct visual features.Neuron · 2024Article
- A pupillary contrast response in mice and humans: Neural mechanisms and visual functions.Neuron · 2024Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types.Nature communications · 2024Article
- Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy.Translational vision science & technology · 2023Article
- Encoding of environmental illumination by primate melanopsin neurons.Science (New York, N.Y.) · 2023Article
- Spike desensitisation as a mechanism for high-contrast selectivity in retinal ganglion cells.Frontiers in cellular neuroscience · 2023Article
- Retinal ganglion cells adapt to ionic stress in experimental glaucoma.Frontiers in neuroscience · 2023Article
- Unified classification of mouse retinal ganglion cells using function, morphology, and gene expression.Cell reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Retinal ganglion cells (RGCs) are the spiking projection neurons of the eye that encode different features of the visual environment. The circuits providing synaptic input to different RGC types to drive feature selectivity have been studied extensively, but there has been less research aimed at understanding the intrinsic properties and how they impact feature selectivity. We introduce an RGC type in the mouse, the Bursty Suppressed-by-Contrast (bSbC) RGC, and compared it to the OFF sustained alpha (OFFsA). Differences in their contrast response functions arose from differences not in synaptic inputs but in their intrinsic properties. Spike generation was the key intrinsic property behind this functional difference; the bSbC RGC undergoes depolarization block while the OFFsA RGC maintains a high spike rate. Our results demonstrate that differences in intrinsic properties allow these two RGC types to detect and relay distinct features of an identical visual stimulus to the brain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.