Evidence map›Paper›PMID 35508143›Full record

ArticleHormone research in paediatrics2022

Histopathological Criteria for Paediatric Adrenocortical Carcinoma.

Victor P Paschoalin, Silvio Tucci Júnior, Andrey G Estevanato, Ricardo B Tiraboschi, Sonir R Antonini, Valdair F Muglia, Fernando Chahud, Livia M Mermejo, José de Bessa Júnior, Carlos A Fernandes Molina

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In one paragraph

Article in Hormone research in paediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Victor P PaschoalinDepartment of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Silvio Tucci JúniorDepartment of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Andrey G EstevanatoDepartment of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Ricardo B TiraboschiDepartment of Surgery, Feira de Santana State University, Feira de Santana, Brazil.
Sonir R AntoniniDepartment of Pediatrics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Valdair F MugliaDepartment of Medical Images, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Fernando ChahudDepartment of Pathology and Legal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Livia M MermejoDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
José de Bessa JúniorDepartment of Surgery, Feira de Santana State University, Feira de Santana, Brazil.
Carlos A Fernandes MolinaDepartment of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Universidade de São Paulo · BRUniversidade Estadual de Feira de Santana · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdrenocortical carcinoma (ACC) is diagnosed in paediatric patients at 5 months after symptom onset on average, and 38% die during the first 2.5 years of follow-up. This study aimed to compare the accuracy of Weiss, Van Slooten, and Wieneke histopathological ACC classifications for predicting follow-up prognosis in a paediatric population.

methodsData were retrieved from medical records of 57 patients aged <18 years who underwent surgical treatment for ACC with surgical follow-up over 6 months or death due to ACC. They were classified into either good (without recurrence/death due to ACC) or poor (with recurrence/death due to ACC) prognosis group. Two expert pathologists classified the ACC surgical specimens according to the Weiss, Van Slooten, and Wieneke criteria.

resultsThe median follow-up duration was 126 (18-225) months in 38 males (66.7%) and 19 females (33.3%) (median age: 3 [1-6.5] years). The good prognosis group was younger than the poor prognosis group (median age: 3 [1.5-6.2] years vs. 5 [2-10] years). Seventeen (29.8%) patients in the poor prognosis group died due to ACC within the first 50 months of surgical follow-up; the earliest death occurred in the fourth follow-up month, and the majority of deaths occurred within 24 months of follow-up. The accuracies of Weiss, Van Slooten, and Wieneke classification systems were 40%, 47%, and 77%, respectively. DISCUSSION/

conclusionThe Wieneke classification showed the best accuracy but was not sufficiently precise to establish reliable prognosis for ACC in the paediatric population. The Wieneke classification had approximately 95% sensitivity and negative predictive value.

Indexed as

Adrenal Cortex NeoplasmsAdrenocortical CarcinomaChildChild, PreschoolFemaleHumansInfantMalePrognosisRetrospective StudiesAdrenal glandsCarcinomaClassificationNeoplasmsPaediatricsPathology

Identifiers

PMID35508143
PMCPMC9677829
OpenAlexW4229049157

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.