Evidence map›Paper›PMID 35508124›Full record

ArticleCell reports2022

An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.

Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Jose J Vasquez, Lara Taniguchi, Katrina Bartas and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. A widespread internal brain state for fentanyl withdrawal.bioRxiv : the preprint server for biology · 2026
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  6. Neural basis of adolescent THC-induced potentiation of opioid responses later in life.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  11. Distinct eLPBTheranostics · 2024
    Article
  12. Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  13. Article
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  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Guilian TianDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
May HuiDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Desiree MacchiaDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Pieter DerdeynProgram in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA 92617, USA.
Alexandra RogersInterdepartmental Neuroscience Program, University of California, Irvine, Irvine, CA 92617, USA.
Elizabeth HubbardDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Chengfeng LiuDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Jose J VasquezDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Lara TaniguchiInterdepartmental Neuroscience Program, University of California, Irvine, Irvine, CA 92617, USA.
Katrina BartasProgram in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, CA 92617, USA.
Sean CarrollDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA.
Kevin T BeierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, CA 92617, USA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA 92617, USA; Department of Biomedical Engineering, University of California, Irvine, Irvine, CA 92617, USA; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92617, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92617, USA; UCI Mind, University of California, Irvine, Irvine, CA 92617, USA. Electronic address: kbeier@uci.edu.
University of California, Irvine · US

Funding

Sculpting the brain: High-resolution spatiotemporally-controlled modulation of memoriesDP2AG067666 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T, CORDER, GREGORY · 2019 to 2022
$3.1M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4M
INVESTIGATING FUNCTION OF NOVEL DRUG-INDUCED SYNAPTIC CHANGES IN THE VTAR00DA041445 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T · 2018 to 2020
$747k
NIA NIH HHS DP2 AG067666NIDA NIH HHS R00 DA041445NIDA NIH HHS R01 DA054374NIGMS NIH HHS T32 GM136624
6 · The paper itself

Abstract

Although midbrain dopamine (DA) circuits are central to motivated behaviors, our knowledge of how experience modifies these circuits to facilitate subsequent behavioral adaptations is limited. Here we demonstrate the selective role of a ventral tegmental area DA projection to the amygdala (VTA

Indexed as

CocaineCocaine-Related DisordersAmygdalaAnxietyDopamineHumansVentral Tegmental AreaCocaineDopamineaddictionanxietycalcium imagingchemogeneticscocaine withdrawalCP: Neurosciencedopamineextended amygdalarabies circuit mappingreinstatement

Identifiers

PMID35508124
PMCPMC9225486
OpenAlexW4229013103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.