ArticleCell metabolism2022
PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
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Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Genome-wide mapping of RNA-protein associations through sequencing.Nature biotechnology · 2026Article
- Glycolysis: The Bridge Between Cellular Interaction and Alzheimer's Disease.Biomolecules · 2026Review
- In Vivo Positron Emission Tomography Imaging of Presynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Integrated proteomic and single-cell transcriptomic profiling elucidates immunomodulatory effects of L-serine in autism spectrum disorder.Scientific reports · 2026Article
- Exercise Reprograms the Spatial Function of Phosphoglycerate Dehydrogenase of a Pathogenic Nuclear Transcription Factor (PHGDH): A Narrative Review.Metabolites · 2026Review
- Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease.Protein science : a publication of the Protein Society · 2026Article
- APOE-ε4 genotype and western diet synergistically aggravate synaptic dysfunction in Alzheimer's disease via D-serine disruption.Alzheimer's research & therapy · 2026Article
- RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia.Frontiers in pharmacology · 2026Article
- Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study.Epilepsia · 2025Article
- CLN5 deficiency impairs glucose uptake and uncovers PHGDH as a potential biomarker in Batten disease.Molecular psychiatry · 2025Article
- A phosphoserine phosphatase variant present in the brain of Alzheimer's disease patients favors nuclear mistargeting.The FEBS journal · 2025Article
- Alcohol consumption and DNA methylation: an epigenome-wide association study within the French E3N cohort.Clinical epigenetics · 2025Article
- Article
- SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders.International journal of molecular sciences · 2025Review
- Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach.Frontiers in cellular neuroscience · 2025Article
- Phosphoglycerate dehydrogenase and Alzheimer's disease.EXCLI journal · 2025Article
- Alzheimer's disease: from early pathogenesis to novel therapeutic approaches.Metabolic brain disease · 2024Review
- Single-Cell Patch-Clamp/Proteomics of Human Alzheimer's Disease iPSC-Derived Excitatory Neurons Versus Isogenic Wild-Type Controls Suggests Novel Causation and Therapeutic Targets.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Xu ChenDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA. Electronic address: x1chen@health.ucsd.edu.
Riccardo CalandrelliDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
John GirardiniDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
Zhangming YanDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Zhiqun TanInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine School of Medicine, Irvine, CA, USA; Department of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, University of California, Irvine School of Medicine, Irvine, CA, USA.
Annie HinikerDepartment of Pathology, University of California, San Diego, La Jolla, CA, USA.
Sheng ZhongDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA; Genemo, Inc., San Diego, CA, USA. Electronic address: szhong@ucsd.edu.
University of California San Diego · USUniversity of California, Irvine · US
Funding
UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0MUCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUERRY Marie PEAVY · 2019 to 2026
$34.9MSingle-Cell Analysis of Aging-Associated 4D Nucleome in the Human HippocampusU01DA052769 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI REN, BING, XU, XIANGMIN · 2020 to 2024
$3.4MNeural circuit mechanisms underlying AD-related memory impairmentsRF1AG065675 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2020 to 2020
$1.9MRevealing protein-protein interactions and RNA-protein interactions at genome-scale in two weeksR01GM138852 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2020 to 2023
$1.5MChemical-Genetic Approaches to Define Lrrk2 Kinase Function in Parkinson DiseaseK08NS090633 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HINIKER, ANNIE E · 2014 to 2018
$1.1MSpatial in situ mapping of RNA-chromatin interactions at transcriptome-and-genome scale in human tissuesUH3CA256960 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2022 to 2023
$1.1MSpatial in situ mapping of RNA-chromatin interactions at transcriptome-and-genome scale in human tissuesUG3CA256960 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHONG, SHENG · 2020 to 2021
$898kNCI NIH HHS UG3 CA256960NCI NIH HHS UH3 CA256960NIA NIH HHS P30 AG062429NIA NIH HHS P50 AG016573NIA NIH HHS RF1 AG065675NIDA NIH HHS U01 DA052769NIGMS NIH HHS R01 GM138852NINDS NIH HHS K08 NS090633
Abstract
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Indexed as
Alzheimer DiseasePhosphoglycerate DehydrogenaseAnimalsBrainCell Line, TumorMiceRNA, MessengerSerinePhosphoglycerate DehydrogenaseRNA, MessengerSerine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.