Evidence map›Paper›PMID 35507916›Full record

ArticleThe journal of physical chemistry. B2022

Cofactor Dynamics Couples the Protein Surface to the Heme in Cytochrome

William Shen, Ruijie D Teo, David N Beratan, Jeffrey J Warren

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 3 countries.

William ShenDepartment of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Ruijie D TeoDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
David N BeratanDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Jeffrey J WarrenDepartment of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.ORCID 0000-0002-1747-3029
Duke University · USSimon Fraser University · CA

Funding

MAPPING OF ELECTRON TUNNELING PATHWAYS IN PROTEINSR01GM048043 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVID BERATAN · 1993 to 2026
$6.0M
NIGMS NIH HHS R01 GM048043
6 · The paper itself

Abstract

Electron transport through biomolecules and in biological transport networks is of great importance to bioenergetics and biocatalysis. More generally, it is of crucial importance to understand how the pathways that connect buried metallocofactors to other cofactors, and to protein surfaces, affect the biological chemistry of metalloproteins. In terms of electron transfer (ET), the strongest coupling pathways usually comprise covalent and hydrogen bonded networks, with a limited number of through-space contacts. Herein, we set out to determine the relative roles of hydrogen bonds involved in ET via an established heme-to-surface tunneling pathway in cytochrome (cyt)

Indexed as

Cytochromes cRutheniumElectronsElectron TransportHemeCytochromes cHemeRuthenium

Identifiers

PMID35507916
PMCPMC9867876
OpenAlexW4229005854

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.