Evidence map›Paper›PMID 35507402›Full record

ArticleCytometry. Part A : the journal of the International Society for Analytical Cytology2022

Redistribution of CD8+ T cell subsets in metastatic renal cell carcinoma patients treated with anti-PD-1 therapy.

Sara De Biasi, Annalisa Guida, Domenico Lo Tartaro, Martina Fanelli, Roberta Depenni, Massimo Dominici, Greg Finak, Camillo Porta, Annamaria Paolini, Rebecca Borella and 4 more

Abstract read
In one paragraph

Article in Cytometry. Part A : the journal of the International Society for Analytical Cytology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Redistribution of CD8+ T cell subsets in metastatic renal cell carcinoma patients treated with anti-PD-1 therapy.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sara De BiasiDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.ORCID 0000-0002-3217-9821
Annalisa GuidaAzienda Ospedaliera Santa Maria, Terni, Italy.
Domenico Lo TartaroDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.
Martina FanelliDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.
Roberta DepenniDepartment of Oncology, University of Modena & Reggio Emilia, Modena, Italy.
Massimo DominiciDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.
Greg FinakFred Hutchinson Cancer Research Center, Seattle, USA.ORCID 0000-0003-4341-9090
Camillo PortaChair of Oncology, University of Bari, Bari, Italy.
Annamaria PaoliniDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.
Rebecca BorellaDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.
Carlo BertoldiDepartment of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Italy.
Andrea CossarizzaDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.ORCID 0000-0002-5381-1558
Roberto SabbatiniDepartment of Oncology, University of Modena & Reggio Emilia, Modena, Italy.
Lara GibelliniDepartment of Medical and Surgical Sciences for Children & Adults, University of Modena and Reggio Emilia, Emilia-Romagna.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal-cell carcinoma (RCC) is responsible for the majority of tumors arising from the kidney parenchyma. Although a progressive improvement in median overall survival has been observed after the introduction of anti-PD-1 therapy, many patients do not benefit from this treatment. Therefore, we have investigated T cell dynamics to find immune modification induced by anti-PD-1 therapy. Here, we show that, after therapy, RCC patients (5 responders and 14 nonresponders) are characterized by a redistribution of different subsets across the memory T cell compartment.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsCD8-Positive T-LymphocytesHumansT-Lymphocyte Subsetsanti-PD-1 therapymRCCsingle-cells technologiesT cellsunsupervised cluster analysis

Identifiers

PMID35507402
PMCPMC9542732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.