Evidence map›Paper›PMID 35507386›Full record

ArticleeLife2022

A discrete parasubthalamic nucleus subpopulation plays a critical role in appetite suppression.

Jessica H Kim, Grace H Kromm, Olivia K Barnhill, Jacob Sperber, Lauren B Heuer, Sierra Loomis, Matthew C Newman, Kenneth Han, Faris F Gulamali, Theresa B Legan and 4 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A Distinct Subpopulation of Extended Amygdala Neurons Drives Food Intake.Biological psychiatry global open science · 2026
    Article
  5. Article
  6. A Distinct Subpopulation of Extended Amygdala Neurons Drives Food Intake.bioRxiv : the preprint server for biology · 2025
    Article
  7. Ingestion-activated CGRP neurons control learning but not satiety.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Unraveling Pallido-Retrorubral Circuits Linking the Basal Ganglia to Limbic Areas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Mouse parasubthalamicbioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Jessica H Kim *Department of Biology, Williams College, Williamstown, United States.ORCID 0000-0002-2498-170X
Grace H Kromm *Department of Biology, Williams College, Williamstown, United States.ORCID 0000-0003-0847-5468
Olivia K Barnhill *Department of Biology, Williams College, Williamstown, United States.ORCID 0000-0003-1597-9701
Jacob SperberDepartment of Biology, Williams College, Williamstown, United States.
Lauren B HeuerDepartment of Biology, Williams College, Williamstown, United States.
Sierra LoomisDepartment of Biology, Williams College, Williamstown, United States.
Matthew C NewmanDepartment of Biology, Williams College, Williamstown, United States.
Kenneth HanDepartment of Biology, Williams College, Williamstown, United States.
Faris F GulamaliDepartment of Biology, Williams College, Williamstown, United States.ORCID 0000-0002-2973-6594
Theresa B LeganDepartment of Biology, Williams College, Williamstown, United States.
Katharine E JensenDepartment of Physics, Williams College, Williamstown, United States.ORCID 0000-0003-1862-8026
Samuel C FunderburkDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, United States.ORCID 0000-0001-5146-2035
Michael J KrashesDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, United States.ORCID 0000-0003-0966-3401
Matthew E CarterDepartment of Biology, Williams College, Williamstown, United States.ORCID 0000-0003-1802-090X
Williams College · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Probing neural circuits underlying satietyZIADK075087 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7M
Investigating addictive/compulsive feeding behaviorZIADK075088 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7M
Investigating the interaction of motivational systemsZIADK075090 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI KRASHES, MICHAEL J. · 2013 to 2025
$4.7M
Determination of how orexigenic AgRP neurons anatomically and functionally interact with anorexigenic PBel CGRP neurons to regulate food intake behaviorR15DK105510 · NIDDK · WILLIAMS COLLEGE · PI CARTER, MATTHEW E · 2015 to 2018
$731k
NIDDK NIH HHS R15 DK105510
6 · The paper itself

Abstract

Food intake behavior is regulated by a network of appetite-inducing and appetite-suppressing neuronal populations throughout the brain. The parasubthalamic nucleus (PSTN), a relatively unexplored population of neurons in the posterior hypothalamus, has been hypothesized to regulate appetite due to its connectivity with other anorexigenic neuronal populations and because these neurons express Fos, a marker of neuronal activation, following a meal. However, the individual cell types that make up the PSTN are not well characterized, nor are their functional roles in food intake behavior. Here, we identify and distinguish between two discrete PSTN subpopulations, those that express tachykinin-1 (PSTN

Indexed as

AppetiteAppetite RegulationAnimalsCorticotropin-Releasing HormoneEatingMiceNeuronsOptogeneticsCorticotropin-Releasing HormoneAgRPenergy homeostasisfeedinghypothalamusmouseneuroscienceparabrachialparasubthalamicPSTN

Identifiers

PMID35507386
PMCPMC9119672
OpenAlexW4225395573

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.