Evidence map›Paper›PMID 35507343›Full record

ArticleJAMA network open2022

Rotating Night Shift Work and Healthy Aging After 24 Years of Follow-up in the Nurses' Health Study.

Hongying Shi, Tianyi Huang, Eva S Schernhammer, Qi Sun, Molin Wang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 55 citations in OpenAlex.

  1. Reimagining Hospital Medicine for Long-Term Sustainability.Journal of general internal medicine · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. BioClocks UK: driving robust cycles of discovery to impact.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Hongying ShiDepartment of Epidemiology and Health Statistics, School of Public Health and Management, Wenzhou Medical University, Zhejiang, China.
Tianyi HuangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Eva S SchernhammerDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Qi SunDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Molin WangDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Harvard University · USBrigham and Women's Hospital · US

Funding

Elucidating Inflammatory and Metabolic Pathways in Obstructive Sleep Apnea DevelopmentK01HL143034 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUANG, TIANYI · 2018 to 2022
$885k
NHLBI NIH HHS K01 HL143034
6 · The paper itself

Abstract

Importance: Rotating night shift work is associated with higher mortality. Whether it is also associated with overall health among those who survive to older ages remains unclear. Objective: To examine whether rotating night shift work is associated with healthy aging after 24 years of follow-up in the Nurses' Health Study, a cohort study among registered female nurses. Design, Setting, and Participants: For this cohort study, a composite healthy aging phenotype was ascertained among 46 318 participants who were aged 46 to 68 years and free of major chronic diseases in 1988 when the history of night shift work was assessed. In a secondary analysis in which cognitive function decline was considered in the healthy aging definition, 14 273 nurses were involved. Data were analyzed from March 1 to September 30, 2021. Exposures: Duration of rotating night shift work. Main Outcomes and Measures: Healthy aging was defined as reaching at least 70 years of age and being free of 11 major chronic diseases, memory impairment, physical limitation, or deteriorated mental health. Results: Of 46 318 female nurses (mean [SD] age at baseline, 55.4 [6.1] years), 3695 (8.0%) achieved healthy aging after 24 years of follow-up. After adjusting for established and potential confounders, compared with women who never worked rotating night shifts, the odds of achieving healthy aging decreased significantly with increasing duration of night shift work. The odds ratios were 0.96 (95% CI, 0.89-1.03) for 1 to 5 years, 0.92 (95% CI, 0.79-1.07) for 6 to 9 years, and 0.79 (95% CI, 0.69-0.91) for 10 or more years of night shift work (P = .001 for trend). This association did not differ substantially by age and lifestyles and was consistent for 4 individual dimensions of healthy aging. Results were similar in a secondary analysis, with an odds ratio of 0.73 (95% CI, 0.60-0.89; P < .001 for trend) comparing 10 or more years of night shift work vs no night shift work. Conclusions and Relevance: In this cohort study, rotating night shift work was associated with decreased probability of healthy aging among US female nurses. These data support the notion that excess night shift work is a significant health concern that may also lead to deteriorated overall health among older individuals.

Indexed as

Healthy AgingNursesShift Work ScheduleAgedCohort StudiesFemaleFollow-Up StudiesHumansMiddle AgedProspective StudiesWork Schedule Tolerance

Identifiers

PMID35507343
PMCPMC9069254
OpenAlexW4225411355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.