Evidence map›Paper›PMID 35507161›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Differentiation of iPS-Cells into Peripheral Sensory Neurons.

Anika Neureiter, Esther Eberhardt, Angelika Lampert

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The pain target NaPflugers Archiv : European journal of physiology · 2024
    Article
  5. Article
  6. Review
  7. Nociception, Transcriptomics ET CETERA: NOCICEPTRA.Pflugers Archiv : European journal of physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anika NeureiterInstitute of Physiology, Uniklinik RWTH Aachen, Aachen, Germany.
Esther EberhardtDepartment of Anesthesiology, Uniklinik RWTH Aachen, Aachen, Germany.
Angelika LampertInstitute of Physiology, Uniklinik RWTH Aachen, Aachen, Germany. alampert@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced pluripotent stem cells (iPS-cells) have significantly expanded our experimental possibilities, by creating new strategies for the molecular study of human disease and drug development. Treatment of pain has not seen much improvement over the past decade, likely due to species differences in preclinical models. Thus, iPS-cell derived sensory neurons offer a highly welcome translational approach for research and drug development. Although central neuronal differentiation is relatively straightforward, the successful and reliable generation of peripheral neurons requires more complex measures. Here, we describe a small molecule-based protocol for the differentiation of human sensory neurons from iPS-cells which renders functional nociceptor-like cells within several weeks.

Indexed as

Induced Pluripotent Stem CellsCell DifferentiationHumansSensory Receptor CellsDifferentiationDisease modelingInduced pluripotent stem cellsiPS-cellsNeural crest cellsPainPeripheral neuronsSensory neuronsSensory neuropathy

Identifiers

PMID35507161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.