Liamocin overproduction by the mutants of Aureobasidium melanogenum 9-1 for effectively killing spores of the pathogenic fungi from diseased human skin by Massoia lactone.

Zhu Wang, Mei Zhang, Zhe Chi, Guang-Lei Liu, Zhen-Ming Chi

Abstract read

In one paragraph

Article in World journal of microbiology & biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

The Pathogenic YeastJournal of fungi (Basel, Switzerland) · 2023
Review
Exploration and Evaluation of Secondary Metabolites fromMolecules (Basel, Switzerland) · 2023
Article

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhu Wang *College of Marine Life Science, Ocean University of China, Yushan Road, No. 5, Qingdao, China.

Mei Zhang *College of Marine Life Science, Ocean University of China, Yushan Road, No. 5, Qingdao, China.

Zhe ChiCollege of Marine Life Science, Ocean University of China, Yushan Road, No. 5, Qingdao, China.

Guang-Lei LiuCollege of Marine Life Science, Ocean University of China, Yushan Road, No. 5, Qingdao, China.

Zhen-Ming ChiCollege of Marine Life Science, Ocean University of China, Yushan Road, No. 5, Qingdao, China. chi@ouc.edu.cn.ORCID http://orcid.org/0000-0002-4491-511X

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 31970058

6 · The paper itself

Abstract

Liamocins and Massoia lactone have many applications. In this study, the glucose-derepressed mutant Δcrea5 in which the CREA gene was removed could produce 36.5 g/L of liamocins. Furthermore, overexpression of the MSN2 gene in the mutant Δcrea5 made the transformant M60 produce 41.4 g/L of liamocins and further overexpression of the GAL1 gene in the transformant M60 rendered the transformant G40 to produce 49.5 ± 0.4 g/L of liamocins during the 10-L fermentation while their wild type strain 9-1 made only 26.3 g/L of liamocins. The expressed transcription activators Msn2 and Gal1 were localized in the nuclei, promoting expression of the genes responsible for liamocins biosynthesis and sugar transport. Massoia lactone prepared from the produced liamocins could actively kill the spores of the pathogenic fungi from the diseased human skin by inhibiting spore germination and causing cellular necrosis of the fungal spores.

Indexed as

AureobasidiumLactonesFermentationHumansSpores, FungalLactonesGlucose de-repressionKilling of pathogenic fungal sporesLiamocinsMassoia lactoneOverexpression

Identifiers

PMID35507122

DOI10.1007/s11274-022-03290-9

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.