Evidence map›Paper›PMID 35506879›Full record

ArticleBiochemistry2022

Domain Fusion of Two Oxygenases Affords Organophosphonate Degradation in Pathogenic Fungi.

Michelle Langton, Matthew Appell, Jeremy Koob, Maria-Eirini Pandelia

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Biochemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michelle LangtonDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Matthew AppellDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Jeremy KoobDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.
Maria-Eirini PandeliaDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02453, United States.ORCID 0000-0002-6750-1948
Brandeis University · US

Funding

How does a metallofactor in Hepatitis B viral protein X orchestrate pathogenesis and liver cancerR01GM126303 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2019 to 2023
$1.8M
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaR00GM111978 · NIGMS · BRANDEIS UNIVERSITY · PI PANDELIA, MARIA-EIRINI · 2016 to 2018
$740k
Functional diversification of the HD-superfamily; the Hydrolase/Oxygenase DilemmaK99GM111978 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PANDELIA, MARIA-EIRINI · 2014 to 2015
$107k
NIGMS NIH HHS K99 GM111978NIGMS NIH HHS R00 GM111978NIGMS NIH HHS R01 GM126303
6 · The paper itself

Abstract

Proteins of the HD-domain superfamily employ a conserved histidine-aspartate (HD) dyad to coordinate diverse metallocofactors. While most known HD-domain proteins are phosphohydrolases, new additions to this superfamily have emerged such as oxygenases and lyases, expanding their functional repertoire. To date, three HD-domain oxygenases have been identified, all of which employ a mixed-valent Fe

Indexed as

OrganophosphonatesOxygenasesFerric CompoundsFungiOxygenPhylogenyFerric CompoundsOrganophosphonatesOxygenOxygenases

Identifiers

PMID35506879
PMCPMC9177745
OpenAlexW4229049833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.