Evidence map›Paper›PMID 35506752›Full record

ArticleScandinavian journal of immunology2022

Increased proportions of inflammatory T cells and their correlations with cytokines and clinical parameters in patients with ankylosing spondylitis from northern Sweden.

Kristina Lejon, Urban Hellman, Lan Do, Anjani Kumar, Helena Forsblad-d'Elia

Abstract read
In one paragraph

Article in Scandinavian journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Uncovering the Underworld of Axial Spondyloarthritis.International journal of molecular sciences · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristina LejonDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0001-5025-6539
Urban HellmanDivision of Medicine, Department of Public Health and Clinical Medicine, Section of Rheumatology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0002-3822-0725
Lan DoDivision of Medicine, Department of Public Health and Clinical Medicine, Section of Rheumatology, Umeå University, Umeå, Sweden.
Anjani KumarDivision of Medicine, Department of Public Health and Clinical Medicine, Section of Rheumatology, Umeå University, Umeå, Sweden.
Helena Forsblad-d'EliaDivision of Medicine, Department of Public Health and Clinical Medicine, Section of Rheumatology, Umeå University, Umeå, Sweden.ORCID https://orcid.org/0000-0001-7871-5303

Funding

County of Västerbotten ALFVLL-640251Heart FoundationKing Gustaf Vth 80-year Foundation FAI-2017-0454Mats Kleberg's FoundationSwedish Research CouncilThe Norrland's Heart FoundationThe Swedish Association Against RheumatismThe Swedish Research Council 2016-02035Umeå UniversitetVästerbotten's Association Against Rheumatism
6 · The paper itself

Abstract

Ankylosing spondylitis (AS) is an autoimmune disease affecting parts of the skeletal structure in particular. Previously increased levels of the inflammatory cell types Th17, Th22, Tc17 and Tc22 cells have been shown to be associated with AS. Here, we analysed the levels of inflammatory T cell subsets, related cytokines and clinical characteristics of AS patients vs controls from northern Sweden. Peripheral blood mononuclear cells (PBMCs) obtained from 50 AS patients and 50 matched controls were short term stimulated with PMA/Ionomycin, stained and analysed by flow cytometry. Plasma levels of Interleukin (IL)-17, IL-22, IL-10 as well as clinically relevant markers were determined. Compared to male controls, male AS patients showed 1.5- to 2-fold increases of Th17 (P = .013), Th22 (P = .003) and Tc22 (P = .024) among CD45

Indexed as

Spondylitis, AnkylosingCytokinesFemaleHumansInterleukin-10Leukocytes, MononuclearMaleSwedenTh17 CellsT-Lymphocyte SubsetsCytokinesInterleukin-10ankylosing spondylitisradiographic axial spondyloarthritisT cells

Identifiers

PMID35506752
PMCPMC9539637

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.