Evidence map›Paper›PMID 35506667›Full record

ArticlemBio2022

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle.

Larissa Kever, Aël Hardy, Tom Luthe, Max Hünnefeld, Cornelia Gätgens, Lars Milke, Johanna Wiechert, Johannes Wittmann, Cristina Moraru, Jan Marienhagen and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  4. DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  14. Systematic functional assessment of anti-phage systems in their native host.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Larissa Kever *Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Aël Hardy *Institute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Tom LutheInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Max HünnefeldInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Cornelia GätgensInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Lars MilkeInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Johanna WiechertInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Johannes WittmannLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Cristina MoraruInstitute for Chemistry and Biology of the Marine Environment, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.
Jan MarienhagenInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Julia FrunzkeInstitute of Bio- und Geosciences, IBG-1: Biotechnology, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.ORCID 0000-0001-6209-7950
Forschungszentrum Jülich · DECarl von Ossietzky Universität Oldenburg · DELeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In response to viral predation, bacteria have evolved a wide range of defense mechanisms, which rely mostly on proteins acting at the cellular level. Here, we show that aminoglycosides, a well-known class of antibiotics produced by

Indexed as

BacteriophagesAminoglycosidesAnti-Bacterial AgentsAntiviral AgentsEscherichia coliAminoglycosidesAnti-Bacterial AgentsAntiviral Agentsaminoglycosidesantibioticsbacteriophagesphage defensephage-host interactionStreptomyces

Identifiers

PMID35506667
PMCPMC9239200
OpenAlexW4229046765

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.