Evidence map›Paper›PMID 35506650›Full record

ArticleeLife2022

Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in

Haikel Dridi, Frances Forrester, Alisa Umanskaya, Wenjun Xie, Steven Reiken, Alain Lacampagne, Andrew Marks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  4. Targeting ryanodine receptors to treat human diseases.The Journal of clinical investigation · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haikel DridiDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.ORCID 0000-0001-9533-7367
Frances ForresterDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.
Alisa UmanskayaDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.
Wenjun XieDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.
Steven ReikenDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.
Alain LacampagnePhyMedExp, Montpellier University, INSERM, CNRS, CHRU Montpellier, Montpellier, France.
Andrew MarksDepartment of Physiology and Cellular Biophysics, The Clyde and Helen Wu Center for Molecular Cardiology, New York, United States.ORCID 0000-0002-8057-1502
Centre National de la Recherche Scientifique · FR

Funding

MOLECULAR BASIS OF HEART FAILURER01HL061503 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 1998 to 2016
$6.5M
Exploring the Molecular Physiology of Atrial FibrillationR01HL140934 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, MARX, STEVEN O · 2018 to 2025
$6.0M
Training in Cardiovascular Translational ResearchT32HL120826 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, TABAS, IRA A · 2014 to 2023
$4.7M
Structure-function analysis for elucidating pathogenicity of cardiac ryanodine receptor genetic variantsR01HL145473 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, SHEPARD, KENNETH L · 2019 to 2022
$3.1M
LIVOPT -- LIVer cirrhosis - Optimizing Prediction of Patient OuTcomesR01AG070194 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LADNER, DANIELA P, MEHROTRA, SANJAY · 2021 to 2025
$3.1M
Ryanodine Receptor Defects in Cardiomyopathy Caused by Lamin A/C Gene MutationsR01HL142903 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT, WORMAN, HOWARD J · 2019 to 2022
$1.8M
Calcium and the physiology of diabetesR01DK118240 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARKS, ANDREW ROBERT · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL061503NHLBI NIH HHS R01 HL140934NHLBI NIH HHS R01 HL142903NHLBI NIH HHS R01 HL145473NHLBI NIH HHS T32 HL120826NIA NIH HHS R01 AG070194NIDDK NIH HHS R01 DK118240
6 · The paper itself

Abstract

Age-dependent loss of body wall muscle function and impaired locomotion occur within 2 weeks in

Indexed as

Caenorhabditis elegans ProteinsRyanodine Receptor Calcium Release ChannelAnimalsCaenorhabditis elegansCalciumCalcium SignalingMammalsMiceMuscle, SkeletalSarcoplasmic ReticulumCaenorhabditis elegans ProteinsCalciumRyanodine Receptor Calcium Release ChannelUnc-68 protein, C elegansagingbiochemistrycalciumC. eleganscell biologychemical biologyoxidative stressskeletal muscleUNC-68

Identifiers

PMID35506650
PMCPMC9113742
OpenAlexW4225380712

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.